Exogenous pathway is a process for delivering triglycerides to peripheral tissues using chylomicrons and VLDLs

The exogenous pathway is a process for delivering triglycerides to peripheral tissues using chylomicrons and VLDLs. Chylomicron particles, consisting of APOB-48 and various other proteins, are formed by enterocytes, released into the lymph, and eventually enter the bloodstream. In peripheral tissues, chylomicron triglycerides are broken down, and the remnants are taken up by the liver, while APOA and APOC return to HDL. In the endogenous pathway, the liver produces triglycerides carried to peripheral tissues by VLDL. These VLDL particles initially contain APOB100 and acquire additional proteins and cholesteryl esters from HDL. In peripheral tissues, VLDL triglycerides are partially broken down into VLDL remnants, which are either absorbed by the liver or converted into LDL
Exogenous pathway is a process for delivering triglycerides to peripheral tissues using chylomicrons and VLDLs

Publication

The Role of Apolipoproteins in the Commonest Cancers: A Review (2023) Nour M. Darwish, et al. Cancers (Basel). 2023 Dec;15(23). Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates ApoB-48 APOB-48 ncbigene_synonym APOB 338
Homo sapiens Primates TAG TAG ncbigene_synonym TMED7 51014
Homo sapiens Primates TAG TAG ncbigene_synonym LINC01194 404663
Homo sapiens Primates LDL-R LDLR ncbigene_symbol LDLR 3949
Homo sapiens Primates LPL LPL ncbigene_symbol LPL 4023
Homo sapiens Primates LPL LPL ncbigene_synonym LCP1 3936
Homo sapiens Primates +Apo-E APOE ncbigene_symbol APOE 348

Chemical mentions

Word Match MeSH Name ChEBI
Fatty Acids fatty acids fatty acids chebi:35366
VLDL VLDL chebi:39027
Triglycerides triglycerides a triacylglycerol chebi:17855

Disease mentions

Word Match MeSH Name DOID