Exogenous pathway is a process for delivering triglycerides to peripheral tissues using chylomicrons and VLDLs
The exogenous pathway is a process for delivering triglycerides to peripheral tissues using chylomicrons and VLDLs. Chylomicron particles, consisting of APOB-48 and various other proteins, are formed by enterocytes, released into the lymph, and eventually enter the bloodstream. In peripheral tissues, chylomicron triglycerides are broken down, and the remnants are taken up by the liver, while APOA and APOC return to HDL. In the endogenous pathway, the liver produces triglycerides carried to peripheral tissues by VLDL. These VLDL particles initially contain APOB100 and acquire additional proteins and cholesteryl esters from HDL. In peripheral tissues, VLDL triglycerides are partially broken down into VLDL remnants, which are either absorbed by the liver or converted into LDL
