Possible mechanisms by which exercise upregulates NAD+ to improve mitochondrial autophagy
Possible mechanisms by which exercise upregulates NAD+ to improve mitochondrial autophagy. Exercise promotes SLC12A8 expression, which allows more NMN to enter the cell membrane from the extracellular fluid, and NMNAT2 in the cytoplasm converts NMN to NAD+. NAD+ in the cytoplasm can enter the nucleus or the mitochondria via SLC25A51. NAD+ entering the mitochondria activates the SIRT1–PGC-1α signaling pathway. Transfer of PGC-1α from the nucleus to the mitochondria activates Mfn1/2 to mediate mitochondrial fusion and improve mitochondrial autophagy
Publication
Effect of Exercise and Oral Niacinamide Mononucleotide on Improving Mitochondrial Autophagy in Alzheimer’s Disease (2023) Weijia Wu, et al. Nutrients. 2023 Jul;15(13). Figure: F4.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | POC | POC | ncbigene_synonym | POMC | 5443 |
| Homo sapiens | Primates | POC1a | POC1A | ncbigene_symbol | POC1A | 25886 |
| Homo sapiens | Primates | NMNAT2 | NMNAT2 | ncbigene_symbol | NMNAT2 | 23057 |
| Homo sapiens | Primates | SIRT1 | SIRT1 | ncbigene_symbol | SIRT1 | 23411 |
| Homo sapiens | Primates | -SLC25A51 | SLC25A51 | ncbigene_symbol | SLC25A51 | 92014 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| NMN | NMN | 3-carbamoyl-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridinium | chebi:16171 | |
| NMN | NMN | 3-carbamoyl-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridinium | chebi:16171 | |
| NMN | NMN | 3-carbamoyl-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridinium | chebi:16171 | |
| NAD | NAD | adenosine 5'-{3-[1-(3-carbamoylpyridinio)-1,4-anhydro-D-ribitol-5-yl] dihydrogen diphosphate} | chebi:15846 | |
| NAD | NAD | adenosine 5'-{3-[1-(3-carbamoylpyridinio)-1,4-anhydro-D-ribitol-5-yl] dihydrogen diphosphate} | chebi:15846 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
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