KEGG pathway analysis of glycolysis and gluconeogenesis
KEGG pathway analysis of glycolysis and gluconeogenesis. (A) Enzymes in red have increased expression in the opioid specimens compared to the naïve. Expression of the enzymes in blue is decreased. Values are log2-transformed fold-change values between the opioid specimens compared with the naïve specimens. (B) Boxplots representing the mRNA expression of selected members of glycolysis (ACSS1: acyl-CoA synthetase short chain family member 1; ALDH3B1: aldehyde dehydrogenase 3 family member B1; ENO1: enolase 1; G6PC2: glucose-6-phosphatase catalytic subunit 2; LDHB: lactate dehydrogenase B; PCK2: phosphoenolpyruvate carboxykinase 2; PDHA1: pyruvate dehydrogenase E1 alpha 1 subunit; PFKFB1: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1; PGM2: phosphoglucomutase 2). * indicates that the gene is significantly regulated between the 2 groups (p < 0.05)
Publication
Extended Opioid Exposure Modulates the Molecular Metabolism of Clear Cell Renal Cell Carcinoma (2023) Mamatha Garige, et al. Life (Basel). 2023 May;13(5). Figure: F3.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | hexokinase | HEXOKINASE | ncbigene_synonym | HK1 | 3098 |
| Homo sapiens | Primates | hexokinase | HEXOKINASE | famplex_relations | GCK | 2645 |
| Homo sapiens | Primates | hexokinase | HEXOKINASE | famplex_relations | HK2 | 3099 |
| Homo sapiens | Primates | hexokinase | HEXOKINASE | famplex_relations | HK3 | 3101 |
| Homo sapiens | Primates | per | PER | ncbigene_synonym | PER1 | 5187 |
| Homo sapiens | Primates | CPM | CPM | ncbigene_symbol | CPM | 1368 |
| Homo sapiens | Primates | (GTP) | GTP | ncbigene_synonym | MTG1 | 92170 |
| Homo sapiens | Primates | *ACSS1 | ACSS1 | ncbigene_symbol | ACSS1 | 84532 |
| Homo sapiens | Primates | ALDH3B1 | ALDH3B1 | ncbigene_symbol | ALDH3B1 | 221 |
| Homo sapiens | Primates | ENO1 | ENO1 | ncbigene_symbol | ENO1 | 2023 |
| Homo sapiens | Primates | G6PC2 | G6PC2 | ncbigene_symbol | G6PC2 | 57818 |
| Homo sapiens | Primates | LDHB | LDHB | ncbigene_symbol | LDHB | 3945 |
| Homo sapiens | Primates | PCK2 | PCK2 | ncbigene_symbol | PCK2 | 5106 |
| Homo sapiens | Primates | *PFKFB1 | PFKFB1 | ncbigene_symbol | PFKFB1 | 5207 |
| Homo sapiens | Primates | PDHA1 | PDHA1 | ncbigene_symbol | PDHA1 | 5160 |
| Homo sapiens | Primates | PGM2 | PGM2 | ncbigene_symbol | PGM2 | 55276 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Arbutin | Arbutin | 4-hydroxyphenyl beta-D-glucopyranoside | chebi:18305 | |
| Arbutin-6P | Arbutin-6P | 4-hydroxyphenyl 6-O-phosphono-beta-D-glucopyranoside | chebi:2807 | |
| Salicin | salicin | salicin | chebi:17814 | |
| Citrate | citrate | chebi:133748 | ||
| acetyl-CoA | acetyl-CoA | 3'-phosphonatoadenosine 5'-(3-{(3R)-4-[(3-{[2-(acetylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl} diphosphate) | chebi:57288 | |
| Acetyl-CoA | acetyl-CoA | 3'-phosphonatoadenosine 5'-(3-{(3R)-4-[(3-{[2-(acetylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl} diphosphate) | chebi:57288 | |
| D-Glucose | D-glucose | D-glucose | chebi:4167 | |
| Pentose | pentose | chebi:25901 | ||
| phosphate | Phosphate | tetraoxophosphoric acid | chebi:26078 | |
| phosphate | Phosphate | tetraoxophosphoric acid | chebi:26078 | |
| phosphoenolpyruvate | phosphoenolpyruvate | 2-(phosphonoatooxy)prop-2-enoate | chebi:58702 | |
| pyruvate | pyruvate | pyruvate | chebi:15361 | |
| Pyruvate | pyruvate | pyruvate | chebi:15361 | |
| ThPP | ThPP | 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-[2-(diphosphooxy)ethyl]-4-methyl-1,3-thiazol-3-ium | chebi:9532 | |
| Acetate | acetate | acetate | chebi:30089 | |
| Acetaldehyde | acetaldehyde | acetaldehyde | chebi:15343 | |
| pyruvate | pyruvate | pyruvate | chebi:15361 | |
| Phosphoenolpyruvate | phosphoenolpyruvate | 2-(phosphonoatooxy)prop-2-enoate | chebi:58702 | |
| Pyruvate | pyruvate | pyruvate | chebi:15361 | |
| L-lactate | L-lactate | (S)-lactate | chebi:16651 | |
| L-Lactate | L-lactate | (S)-lactate | chebi:16651 | |
| Ethanol | ethanol | ethanol | chebi:16236 | |
| Group | group | group | chebi:24433 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|