Insights into the pharmacological and therapeutic effects of apigenin in liver injuries and diseases
Protective effects of APG on HCC. The combination of APG and ADM reverses the drug-resistant phenotype through various pathways. The combination of sorafenib and APG can reduce cell viability, induce apoptosis, and reduce the ability of cancer cells to migrate and invade. The combination of APG and paclitaxel inhibits the expression of HIF-1a and reverses the drug resistance induced by hypoxia. As a signal, APG can reduce the expression of Snai1 and NF-κB, reverse the elevation of EMT, increase cell adhesion, and inhibit the invasion and migration of HCC cells. APG downregulates H19 expression to inhibit the growth of liver cancer cells, inducing inactivation of the canonical Wnt/β-catenin signaling pathway. ADM: Adriamycin, APG: Apigenin, EMT: Epithelial-mesenchymal transition, HCC: Hepatocellular carcinoma.
Publication
Insights into the pharmacological and therapeutic effects of apigenin in liver injuries and diseases. (2023) Chenchen Bi, et al. Heliyon. 2023 May;9(5):e15609. Figure: F3.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | HCC | HCC | ncbigene_symbol | HCC | 619501 |
| Homo sapiens | Primates | HCC | HCC | ncbigene_synonym | HYCC1 | 84668 |
| Homo sapiens | Primates | ADM | ADM | ncbigene_symbol | ADM | 133 |
| Homo sapiens | Primates | MiR-520b/ATG7 | ATG7 | ncbigene_symbol | ATG7 | 10533 |
| Homo sapiens | Primates | MiR-520b | MIR520B | ncbigene_symbol | MIR520B | 574473 |
| Homo sapiens | Primates | B-catenin | CTNNB1 | ncbigene_symbol | CTNNB1 | 1499 |
| Homo sapiens | Primates | Wnt/B-catenin | WNT | famplex_relations | WNT1 | 7471 |
| Homo sapiens | Primates | Wnt/B-catenin | WNT | famplex_relations | WNT2 | 7472 |
| Homo sapiens | Primates | Wnt/B-catenin | WNT | famplex_relations | WNT2B | 7482 |
| Homo sapiens | Primates | Wnt/B-catenin | WNT | famplex_relations | WNT3 | 7473 |
| Homo sapiens | Primates | Wnt/B-catenin | WNT | famplex_relations | WNT3A | 89780 |
| Homo sapiens | Primates | Wnt/B-catenin | WNT | famplex_relations | WNT4 | 54361 |
| Homo sapiens | Primates | Wnt/B-catenin | WNT | famplex_relations | WNT6 | 7475 |
| Homo sapiens | Primates | Wnt/B-catenin | WNT | famplex_relations | WNT7A | 7476 |
| Homo sapiens | Primates | Wnt/B-catenin | WNT | famplex_relations | WNT7B | 7477 |
| Homo sapiens | Primates | Wnt/B-catenin | WNT | famplex_relations | WNT8A | 7478 |
| Homo sapiens | Primates | Wnt/B-catenin | WNT | famplex_relations | WNT8B | 7479 |
| Homo sapiens | Primates | Wnt/B-catenin | WNT | famplex_relations | WNT9A | 7483 |
| Homo sapiens | Primates | Wnt/B-catenin | WNT | famplex_relations | WNT9B | 7484 |
| Homo sapiens | Primates | Wnt/B-catenin | WNT | famplex_relations | WNT10A | 80326 |
| Homo sapiens | Primates | Wnt/B-catenin | WNT | famplex_relations | WNT10B | 7480 |
| Homo sapiens | Primates | Wnt/B-catenin | WNT | famplex_relations | WNT11 | 7481 |
| Homo sapiens | Primates | Wnt/B-catenin | WNT | famplex_relations | WNT16 | 51384 |
| Homo sapiens | Primates | Wnt/B-catenin | WNT | famplex_relations | WNT5A | 7474 |
| Homo sapiens | Primates | Wnt/B-catenin | WNT | famplex_relations | WNT5B | 81029 |
| Homo sapiens | Primates | H19↓ | H19 | ncbigene_symbol | H19 | 283120 |
| Homo sapiens | Primates | H19↓ | H19 | ncbigene_synonym | H1-9P | 373861 |
| Homo sapiens | Primates | MiR-101/nrf2 | NRF2 | ncbigene_synonym | GABPA | 2551 |
| Homo sapiens | Primates | MiR-101/nrf2 | NRF2 | ncbigene_synonym | NFE2L2 | 4780 |
| Homo sapiens | Primates | PI3K/AKT/Nrf2+ | AKT | ncbigene_synonym | AKT1 | 207 |
| Homo sapiens | Primates | PI3K/AKT/Nrf2+ | AKT | famplex_relations | AKT2 | 208 |
| Homo sapiens | Primates | PI3K/AKT/Nrf2+ | AKT | famplex_relations | AKT3 | 10000 |
| Homo sapiens | Primates | PI3K/AKT/Nrf2+ | PI3K | ncbigene_synonym | PIK3CA | 5290 |
| Homo sapiens | Primates | PI3K/AKT/Nrf2+ | PI3K | ncbigene_synonym | PIK3CB | 5291 |
| Homo sapiens | Primates | PI3K/AKT/Nrf2+ | PI3K | ncbigene_synonym | PIK3CD | 5293 |
| Homo sapiens | Primates | PI3K/AKT/Nrf2+ | PI3K | ncbigene_synonym | PIK3CG | 5294 |
| Homo sapiens | Primates | PI3K/AKT/Nrf2+ | PI3K | famplex_relations | PIK3R3 | 8503 |
| Homo sapiens | Primates | PI3K/AKT/Nrf2+ | PI3K | famplex_relations | PIK3R4 | 30849 |
| Homo sapiens | Primates | PI3K/AKT/Nrf2+ | PI3K | famplex_relations | PIK3R5 | 23533 |
| Homo sapiens | Primates | PI3K/AKT/Nrf2+ | PI3K | famplex_relations | PIK3R6 | 146850 |
| Homo sapiens | Primates | PI3K/AKT/Nrf2+ | PI3K | famplex_relations | PIK3R1 | 5295 |
| Homo sapiens | Primates | PI3K/AKT/Nrf2+ | PI3K | famplex_relations | PIK3R2 | 5296 |
| Homo sapiens | Primates | EMT↓ | EMT | ncbigene_synonym | ITK | 3702 |
| Homo sapiens | Primates | EMT↓ | EMT | ncbigene_synonym | SLC22A3 | 6581 |
| Homo sapiens | Primates | Snail | SNAIL | ncbigene_synonym | SNAI1 | 6615 |
| Homo sapiens | Primates | NF-kB | NF-KB | ncbigene_synonym | NFKB1 | 4790 |
| Homo sapiens | Primates | HO-1, | HO-1 | ncbigene_synonym | HMOX1 | 3162 |
| Homo sapiens | Primates | MRPS+ | MRPS | ncbigene_synonym | MRPS7 | 51081 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS2 | 51116 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS5 | 64969 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS6 | 64968 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS9 | 64965 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS10 | 55173 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS11 | 64963 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS12 | 6183 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS14 | 63931 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS15 | 64960 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS16 | 51021 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS17 | 51373 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS18A | 55168 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS18B | 28973 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS18C | 51023 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS21 | 54460 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS22 | 56945 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS23 | 51649 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS24 | 64951 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS25 | 64432 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS26 | 64949 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS27 | 23107 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS28 | 28957 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | DAP3 | 7818 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS30 | 10884 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS31 | 10240 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS33 | 51650 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS34 | 65993 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS35 | 60488 |
| Homo sapiens | Primates | MRPS+ | MRPS | famplex_relations | MRPS36 | 92259 |
| Homo sapiens | Primates | HIF-la, | HIF-1A | ncbigene_synonym | HIF1A | 3091 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|