Proposed model of PAK5-AIF signaling pathway in breast cancer proliferation

Proposed model of PAK5-AIF signaling pathway in breast cancer proliferation. In breast cancer cells, on the one hand, PAK5 prevents AIF from releasing from mitochondria by changing mitochondrial membrane permeability and membrane potential; on the other hand, PAK5 prevents AIF entering the nucleus through the phosphorylation of AIF in cytoplasm, thus inhibiting cell apoptosis.
Proposed model of PAK5-AIF signaling pathway in breast cancer proliferation
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Publication

PAK5-mediated AIF phosphorylation inhibits its nuclear translocation and promotes breast cancer tumorigenesis. (2021) Yao Xing, et al. Int J Biol Sci. 2021;17(5):1315-1327. Figure: F7.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates PAK5 PAK5 ncbigene_symbol PAK5 57144
Homo sapiens Primates PAK5 PAK5 ncbigene_synonym PAK6 56924
Homo sapiens Primates PAK5 PAK5 ncbigene_synonym BUB1B-PAK6 106821730
Homo sapiens Primates Bax BAX ncbigene_symbol BAX 581
Homo sapiens Primates BCL2 BCL2 ncbigene_symbol BCL2 596
Homo sapiens Primates AIF AIF ncbigene_synonym AIFM1 9131
Homo sapiens Primates B1 B1 ncbigene_synonym B3GNT2 10678
Homo sapiens Primates B1 B1 ncbigene_synonym B3GNTL1 146712
Homo sapiens Primates Imp IMP ncbigene_synonym IMPA1 3612
Homo sapiens Primates Imp IMP ncbigene_synonym BRAP 8315
Homo sapiens Primates Impa3/B1 IMPA3 ncbigene_synonym BPNT2 54928
Homo sapiens Primates Caspase-independent CASPASE famplex_relations CASP1 834
Homo sapiens Primates Caspase-independent CASPASE famplex_relations CASP2 835
Homo sapiens Primates Caspase-independent CASPASE famplex_relations CASP4 837
Homo sapiens Primates Caspase-independent CASPASE famplex_relations CASP5 838
Homo sapiens Primates Caspase-independent CASPASE famplex_relations CASP6 839
Homo sapiens Primates Caspase-independent CASPASE famplex_relations CASP8 841
Homo sapiens Primates Caspase-independent CASPASE famplex_relations CASP9 842
Homo sapiens Primates Caspase-independent CASPASE famplex_relations CASP10 843
Homo sapiens Primates Caspase-independent CASPASE famplex_relations CASP12 100506742
Homo sapiens Primates Caspase-independent CASPASE famplex_relations CASP14 23581
Homo sapiens Primates Caspase-independent CASPASE famplex_relations CASP3 836
Homo sapiens Primates Caspase-independent CASPASE famplex_relations CASP7 840
Mus musculus Rodents PAK5 PAK5 ncbigene_symbol Pak5 241656
Mus musculus Rodents Bax BAX ncbigene_symbol Bax 12028
Mus musculus Rodents Bax BAX ncbigene_synonym Nkx3-1 18095
Mus musculus Rodents BCL2 BCL2 ncbigene_symbol Bcl2 12043
Mus musculus Rodents AIF AIF ncbigene_synonym Aifm1 26926
Mus musculus Rodents B1 B1 ncbigene_synonym Hbb-b1 15129
Mus musculus Rodents B1 B1 ncbigene_synonym B3gnt9 97440
Mus musculus Rodents Imp IMP ncbigene_synonym Brap 72399
Bos taurus Mammals PAK5 PAK5 ncbigene_symbol PAK5 513432
Bos taurus Mammals Bax BAX ncbigene_symbol BAX 280730
Bos taurus Mammals BCL2 BCL2 ncbigene_symbol BCL2 281020
Bos taurus Mammals AIF AIF ncbigene_synonym AIF1 280989
Drosophila melanogaster Invertebrates BCL2 BCL2 ncbigene_synonym Debcl 53585
Drosophila melanogaster Invertebrates AIF AIF ncbigene_symbol AIF 33390
Drosophila melanogaster Invertebrates B1 B1 ncbigene_synonym egh 31239
Drosophila melanogaster Invertebrates B1 B1 ncbigene_synonym LanB1 34068
Drosophila melanogaster Invertebrates B1 B1 ncbigene_synonym betaTub56D 37238
Drosophila melanogaster Invertebrates B1 B1 ncbigene_synonym mys 44885
Drosophila melanogaster Invertebrates B1 B1 ncbigene_synonym Prosbeta1 46058
Drosophila melanogaster Invertebrates Imp IMP ncbigene_symbol Imp 32009
Drosophila melanogaster Invertebrates Imp IMP ncbigene_synonym CG11110 37337
Drosophila melanogaster Invertebrates Imp IMP ncbigene_synonym CG17029 39740
Drosophila melanogaster Invertebrates Imp IMP ncbigene_synonym CG17028 39741
Drosophila melanogaster Invertebrates Imp IMP ncbigene_synonym CG17027 39742
Drosophila melanogaster Invertebrates Imp IMP ncbigene_synonym CG9391 40346
Drosophila melanogaster Invertebrates Imp IMP ncbigene_synonym CG9389 40347
Drosophila melanogaster Invertebrates a3 A3 ncbigene_symbol A3 5657641
Drosophila melanogaster Invertebrates a3 A3 ncbigene_synonym nAChRalpha3 31767
Drosophila melanogaster Invertebrates a3 A3 ncbigene_synonym Prosalpha3 37378
Drosophila melanogaster Invertebrates a3 A3 ncbigene_synonym alphaTub84D 40904
Drosophila melanogaster Invertebrates Impa3/B1 IMPB1 ncbigene_synonym Fs(2)Ket 35336
Drosophila melanogaster Invertebrates Impa3/B1 IMPA3 ncbigene_synonym Kap-alpha3 41158

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Breast cancer NA mesh:D001943