Targeting YAP for PDAC therapy

Targeting YAP for PDAC therapy. There are several strategies for targeting YAP in PDAC. Statin-mediated inhibition of HMG-CoA reductase in the mevalonate pathway reduces the geranylgeranylation and membrane localization of Rho GTPases, restricting YAP nuclear accumulation and thus its activity. Verteporfin and VGLL4-mimicking peptides disrupt the interaction between YAP and TEAD, inhibiting YAP-induced transcription. Metformin activates AMPK, which inhibits YAP both directly and by activating LATS kinases. BET inhibitors oppose the transcription of YAP-regulated genes. Neratinib increases the phosphorylation of LATS1 and YAP, causing YAP cytosolic accumulation and degradation.
Targeting YAP for PDAC therapy
Download JPG
View figure at PMC Read paper at PMC
PMC

Publication

YAP in pancreatic cancer: oncogenic role and therapeutic strategy. (2021) Wenhao Mao, et al. Theranostics. 2021;11(4):1753-1762. Figure: F5.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates SAV1 SAV1 ncbigene_symbol SAV1 60485
Homo sapiens Primates MST1 MST1 ncbigene_symbol MST1 4485
Homo sapiens Primates MST1 MST1 ncbigene_synonym STK4 6789
Homo sapiens Primates MST1/2 MST2 ncbigene_synonym STK3 6788
Homo sapiens Primates LATS1 LATS1 ncbigene_symbol LATS1 9113
Homo sapiens Primates LATS1/2 LATS2 ncbigene_symbol LATS2 26524
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA1 5562
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA2 5563
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAB1 5564
Homo sapiens Primates AMPK AMPK famplex_relations PRKAB2 5565
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG1 5571
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG2 51422
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG3 53632
Homo sapiens Primates YAP YAP ncbigene_synonym YAP1 10413
Homo sapiens Primates Rho RHO ncbigene_symbol RHO 6010
Homo sapiens Primates Rho RHO ncbigene_synonym RHOD 29984
Homo sapiens Primates Rho RHO famplex_relations RHOA 387
Homo sapiens Primates Rho RHO famplex_relations RHOB 388
Homo sapiens Primates Rho RHO famplex_relations RHOC 389
Homo sapiens Primates BET BET ncbigene_synonym DNER 92737
Homo sapiens Primates CTGF CTGF ncbigene_synonym CCN2 1490
Homo sapiens Primates CYR61 CYR61 ncbigene_synonym CCN1 3491
Homo sapiens Primates TEAD TEAD famplex_relations TEAD1 7003
Homo sapiens Primates TEAD TEAD famplex_relations TEAD2 8463
Homo sapiens Primates TEAD TEAD famplex_relations TEAD3 7005
Homo sapiens Primates TEAD TEAD famplex_relations TEAD4 7004
Danio rerio Vertebrates SAV1 SAV1 ncbigene_symbol sav1 447821
Danio rerio Vertebrates MST1 MST1 ncbigene_symbol mst1 259260
Danio rerio Vertebrates LATS1 LATS1 ncbigene_symbol lats1 553164
Danio rerio Vertebrates LATS1/2 LATS2 ncbigene_symbol lats2 567674
Danio rerio Vertebrates Rho RHO ncbigene_symbol rho 30295
Danio rerio Vertebrates Rho RHO ncbigene_synonym rnd2 751645
Danio rerio Vertebrates CTGF CTGF ncbigene_synonym ccn2a 321449
Danio rerio Vertebrates CTGF CTGF ncbigene_synonym ccn2b 100124530
Danio rerio Vertebrates CYR61 CYR61 ncbigene_synonym ccn1 403033
Danio rerio Vertebrates CYR61 CYR61 ncbigene_synonym ccn1l2 553273

Chemical mentions

Word Match MeSH Name ChEBI
Mevalonate NA mesh:D008798
Statins Simvastatin mesh:D019821 simvastatin chebi:9150
Metformin Metformin mesh:D008687 metformin chebi:6801
Mevalonic acid NA mesh:D008798
Neratinib neratinib mesh:C487932 neratinib chebi:61397
Verteporfin NA mesh:C098350

Disease mentions

Word Match MeSH Name DOID