Fibroblast growth factor receptor 4 signalling pathway in cancer

Fibroblast growth factor receptor 4 signalling pathway in cancer. Binding of fibroblast growth factors (FGF) leads to receptor activation, which leads to activation of several downstream signalling pathways, including RAS-RAF-MAPK, PI3K-AKT, signal transducer and activator of transcription (STAT) and phospholipase Cγ (PLCγ). Negative feedback signalling regulate at several levels by induction of negative regulators, including MAPK1 and 3 phosphatase (MKP1 and MKP3). Regulators modulate intracellular signalling through MAP Kinase pathways. These regulations eventually lead to altered cell biology including promotion of cell motility, cell proliferation or inhibition of cell differentiation. DAG: Diacylglycerol; FRS2α: FGFR substrate 2α; GRB2: Growth factor receptor-bound 2; IP3: Inositol triphosphate; P: Phosphorylation; PIP2: Phosphatidylinositol-4,5-biphosphate; PKC: Protein kinase C; Sos: Son of sevenless.
Fibroblast growth factor receptor 4 signalling pathway in cancer
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Publication

Fibroblast growth factor receptor 4 single nucleotide polymorphism Gly388Arg in head and neck carcinomas. (2019) Eva Wimmer, et al. World J Clin Oncol. 2019 Mar 24;10(3):136-148. Figure: F5.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents FGFR4 FGFR4 ncbigene_symbol Fgfr4 14186
Mus musculus Rodents GRB2 GRB2 ncbigene_symbol Grb2 14784
Mus musculus Rodents GAB1 GAB1 ncbigene_symbol Gab1 14388
Mus musculus Rodents PI3K PI3K ncbigene_synonym Pik3r1 18708
Mus musculus Rodents Raf RAF ncbigene_synonym Zhx2 387609
Mus musculus Rodents Ras RAS ncbigene_symbol ras 19412
Mus musculus Rodents Ras RAS ncbigene_synonym Hras 15461
Mus musculus Rodents Ras RAS ncbigene_synonym Kras 16653
Mus musculus Rodents Ras RAS ncbigene_synonym Rem1 19700
Mus musculus Rodents FRS2 FRS2 ncbigene_symbol Frs2 327826
Mus musculus Rodents (МАРК APK ncbigene_symbol Apk 109950
Mus musculus Rodents MKP3 MKP3 ncbigene_synonym Dusp6 67603
Mus musculus Rodents AKT AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents PLC PLC ncbigene_synonym Hspg2 15530
Mus musculus Rodents MKP1 MKP1 ncbigene_synonym Dusp1 19252
Mus musculus Rodents MEK MEK ncbigene_synonym Mdk 17242
Homo sapiens Primates FGFR4 FGFR4 ncbigene_symbol FGFR4 2264
Homo sapiens Primates FGF FGF famplex_relations FGF1 2246
Homo sapiens Primates FGF FGF famplex_relations FGF2 2247
Homo sapiens Primates FGF FGF famplex_relations FGF3 2248
Homo sapiens Primates FGF FGF famplex_relations FGF4 2249
Homo sapiens Primates FGF FGF famplex_relations FGF5 2250
Homo sapiens Primates FGF FGF famplex_relations FGF6 2251
Homo sapiens Primates FGF FGF famplex_relations FGF7 2252
Homo sapiens Primates FGF FGF famplex_relations FGF8 2253
Homo sapiens Primates FGF FGF famplex_relations FGF9 2254
Homo sapiens Primates FGF FGF famplex_relations FGF10 2255
Homo sapiens Primates FGF FGF famplex_relations FGF11 2256
Homo sapiens Primates FGF FGF famplex_relations FGF12 2257
Homo sapiens Primates FGF FGF famplex_relations FGF13 2258
Homo sapiens Primates FGF FGF famplex_relations FGF14 2259
Homo sapiens Primates FGF FGF famplex_relations FGF16 8823
Homo sapiens Primates FGF FGF famplex_relations FGF17 8822
Homo sapiens Primates FGF FGF famplex_relations FGF18 8817
Homo sapiens Primates FGF FGF famplex_relations FGF19 9965
Homo sapiens Primates FGF FGF famplex_relations FGF20 26281
Homo sapiens Primates FGF FGF famplex_relations FGF21 26291
Homo sapiens Primates FGF FGF famplex_relations FGF22 27006
Homo sapiens Primates FGF FGF famplex_relations FGF23 8074
Homo sapiens Primates GRB2 GRB2 ncbigene_symbol GRB2 2885
Homo sapiens Primates GAB1 GAB1 ncbigene_symbol GAB1 2549
Homo sapiens Primates GAB1 GAB1 ncbigene_synonym PIGU 128869
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates Raf RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates Raf RAF famplex_relations ARAF 369
Homo sapiens Primates Raf RAF famplex_relations BRAF 673
Homo sapiens Primates Raf RAF famplex_relations RAF1 5894
Homo sapiens Primates Ras RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras RAS famplex_relations NRAS 4893
Homo sapiens Primates Sos SOS ncbigene_synonym XYLT2 64132
Homo sapiens Primates Sos SOS famplex_relations SOS1 6654
Homo sapiens Primates Sos SOS famplex_relations SOS2 6655
Homo sapiens Primates FRS2 FRS2 ncbigene_symbol FRS2 10818
Homo sapiens Primates MKP3 MKP3 ncbigene_synonym DUSP6 1848
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates PLC PLC ncbigene_synonym HSPG2 3339
Homo sapiens Primates PLC PLC famplex_relations PLCE1 51196
Homo sapiens Primates PLC PLC famplex_relations PLCZ1 89869
Homo sapiens Primates PLC PLC famplex_relations PLCB1 23236
Homo sapiens Primates PLC PLC famplex_relations PLCB2 5330
Homo sapiens Primates PLC PLC famplex_relations PLCB3 5331
Homo sapiens Primates PLC PLC famplex_relations PLCB4 5332
Homo sapiens Primates PLC PLC famplex_relations PLCD1 5333
Homo sapiens Primates PLC PLC famplex_relations PLCD3 113026
Homo sapiens Primates PLC PLC famplex_relations PLCD4 84812
Homo sapiens Primates PLC PLC famplex_relations PLCG1 5335
Homo sapiens Primates PLC PLC famplex_relations PLCG2 5336
Homo sapiens Primates MKP1 MKP1 ncbigene_synonym DUSP1 1843
Homo sapiens Primates PKC PKC ncbigene_synonym PRRT2 112476
Homo sapiens Primates PKC PKC famplex_relations PRKCA 5578
Homo sapiens Primates PKC PKC famplex_relations PRKCB 5579
Homo sapiens Primates PKC PKC famplex_relations PRKCD 5580
Homo sapiens Primates PKC PKC famplex_relations PRKCE 5581
Homo sapiens Primates PKC PKC famplex_relations PRKCG 5582
Homo sapiens Primates PKC PKC famplex_relations PRKCH 5583
Homo sapiens Primates PKC PKC famplex_relations PRKCI 5584
Homo sapiens Primates PKC PKC famplex_relations PRKCQ 5588
Homo sapiens Primates PKC PKC famplex_relations PRKCZ 5590
Homo sapiens Primates PKC PKC famplex_relations PRKD3 23683
Homo sapiens Primates MEK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates MEK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates MEK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Oryctolagus cuniculus Mammals FGFR4 FGFR4 ncbigene_symbol FGFR4 100355275
Oryctolagus cuniculus Mammals GRB2 GRB2 ncbigene_symbol GRB2 100342500
Oryctolagus cuniculus Mammals GAB1 GAB1 ncbigene_symbol GAB1 100346125
Oryctolagus cuniculus Mammals FRS2 FRS2 ncbigene_symbol FRS2 100349995
Capra hircus Mammals FGFR4 FGFR4 ncbigene_symbol FGFR4 102183685
Capra hircus Mammals GRB2 GRB2 ncbigene_symbol GRB2 102170356
Capra hircus Mammals GAB1 GAB1 ncbigene_symbol GAB1 102179970
Capra hircus Mammals FRS2 FRS2 ncbigene_symbol FRS2 102170949
Drosophila melanogaster Invertebrates FGF FGF ncbigene_synonym bnl 42356
Drosophila melanogaster Invertebrates GRB2 GRB2 ncbigene_synonym drk 36497
Drosophila melanogaster Invertebrates GAB1 GAB1 ncbigene_synonym dos 38321
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates Raf RAF ncbigene_symbol Raf 31221
Drosophila melanogaster Invertebrates Ras RAS ncbigene_symbol ras 43873
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras64B 38494
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras85D 41140
Drosophila melanogaster Invertebrates Sos SOS ncbigene_symbol Sos 34790
Drosophila melanogaster Invertebrates (МАРК APK ncbigene_synonym Nplp1 38003
Drosophila melanogaster Invertebrates MKP3 MKP3 ncbigene_symbol Mkp3 40081
Drosophila melanogaster Invertebrates AKT AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates Ca CA ncbigene_symbol ca 43518
Drosophila melanogaster Invertebrates PLC PLC ncbigene_synonym norpA 31376
Drosophila melanogaster Invertebrates PLC PLC ncbigene_synonym sl 32601
Drosophila melanogaster Invertebrates PLC PLC ncbigene_synonym Plc21C 33204
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym inaC 36897
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym Pkc98E 43428
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym aPKC 47594
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym Pkc53E 48311
Drosophila melanogaster Invertebrates box BOX ncbigene_synonym Gclm 248194
Drosophila melanogaster Invertebrates MEK MEK ncbigene_synonym Dsor1 31872
Drosophila melanogaster Invertebrates MEK MEK ncbigene_synonym Mtk 36708
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym MKP-4 32963
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym p38b 34780
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym rl 3354888

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA
Cardiomyopathy NA
Lung cancer NA
Noonan syndrome NA