Simplified scheme of the cholesterol biosynthesis pathway featuring the shunt pathway
Simplified scheme of the cholesterol biosynthesis pathway featuring the shunt pathway. In the shunt pathway SQLE acts a second time to lead to the production of a potent oxysterol regulator, 24(S),25-epoxycholesterol. The oxygen atoms from the epoxidation are shown in red
Publication
The shape of human squalene epoxidase expands the arsenal against cancer. (2019) Andrew J. Brown, et al. Nat Commun. 2019;10:888. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Acetyl-CoA H | Acetyl Coenzyme A | mesh:D000105 | acetyl-CoA | chebi:15351 |
| Isoprenoids | terpene | mesh:D013729 | Terpenes | chebi:35186 |
| ubiquinol | NA | mesh:C003741 | ||
| dolichol | Dolichols | mesh:D004286 | dolichol | chebi:16091 |
| Mevalonate | NA | mesh:D008798 | ||
| Statins | Simvastatin | mesh:D019821 | simvastatin | chebi:9150 |
| Squalene | Squalene | mesh:D013185 | squalene | chebi:15440 |
| Dioxidosqualene | NA | mesh:C015171 | ||
| Oxidosqualene | (S)-2,3-epoxysqualene | mesh:C520393 | oxidosqualene | chebi:15441 |
| Lanosterol | Lanosterol | mesh:D007810 | lanosterol | chebi:16521 |
| 24(S),25-Epoxylanosterol Lanosterol | NA | mesh:C015410 | ||
| 24(S),25-Epoxy | 24(S),25-epoxycholesterol | mesh:C028358 | 24,25-epoxycholesterol | chebi:41633 |
| cholesterol | Cholesterol | mesh:D002784 | cholesterol | chebi:16113 |
| Cholesterol | Cholesterol | mesh:D002784 | cholesterol | chebi:16113 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|