Incorporation of arachidonic acid into membrane-bound phospholipids by the Lands pathway ()
Incorporation of arachidonic acid into membrane-bound phospholipids by the Lands pathway (). Free AA is converted to the CoA ester and then a substrate for lysophospholipid acyltransferases located in the ER for incorporation into membrane phospholipids. The free AA can also be a substrate for various oxidation reactions to form bioactive eicosanoids or β-oxidation, while CoA esters can be substrates for acyltransferases to for cholesteryl esters or diacyl- and triacylglycerols.
Publication
Lysophospholipid acyltransferases and leukotriene biosynthesis: intersection of the Lands cycle and the arachidonate PI cycle. (2019) Robert C. Murphy, et al. J Lipid Res. 2019 Feb;60(2):219-226. Figure: F2.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | LPCAТЗ, | LPCAT | ncbigene_synonym | LPCAT3 | 10162 |
| Homo sapiens | Primates | LPCAТЗ, | LPCAT | ncbigene_synonym | LPCAT1 | 79888 |
| Homo sapiens | Primates | LPCAТЗ, | LPCAT | ncbigene_synonym | MBOAT2 | 129642 |
| Homo sapiens | Primates | МBOAT7/LPIAT/ | LPIAT | ncbigene_synonym | MBOAT7 | 79143 |
| Homo sapiens | Primates | COX1/2 | COX2 | ncbigene_symbol | COX2 | 4513 |
| Homo sapiens | Primates | COX1/2 | COX2 | ncbigene_synonym | PTGS2 | 5743 |
| Homo sapiens | Primates | COX1/2 | COX2 | ncbigene_synonym | MTCO2P12 | 107075310 |
| Homo sapiens | Primates | COX1/2 | COX1 | ncbigene_symbol | COX1 | 4512 |
| Homo sapiens | Primates | COX1/2 | COX1 | ncbigene_synonym | PTGS1 | 5742 |
| Homo sapiens | Primates | COX1/2 | C2 | ncbigene_symbol | C2 | 717 |
| Homo sapiens | Primates | 5LO | 5LO | ncbigene_synonym | ALOX5 | 240 |
| Homo sapiens | Primates | LOX | LOX | ncbigene_symbol | LOX | 4015 |
| Homo sapiens | Primates | P450, | P450 | ncbigene_synonym | CYP2B6 | 1555 |
| Homo sapiens | Primates | MGAT | MGAT | ncbigene_synonym | MGAT1 | 4245 |
| Homo sapiens | Primates | MGAT | MGAT | famplex_relations | MGAT2 | 4247 |
| Homo sapiens | Primates | MGAT | MGAT | famplex_relations | MGAT3 | 4248 |
| Homo sapiens | Primates | MGAT | MGAT | famplex_relations | MGAT4A | 11320 |
| Homo sapiens | Primates | MGAT | MGAT | famplex_relations | MGAT4B | 11282 |
| Homo sapiens | Primates | MGAT | MGAT | famplex_relations | MGAT4C | 25834 |
| Homo sapiens | Primates | MGAT | MGAT | famplex_relations | MGAT4D | 152586 |
| Homo sapiens | Primates | MGAT | MGAT | famplex_relations | MGAT5 | 4249 |
| Homo sapiens | Primates | MGAT | MGAT | famplex_relations | MGAT5B | 146664 |
| Homo sapiens | Primates | НЕTES) | TES | ncbigene_symbol | TES | 26136 |
| Homo sapiens | Primates | ACAT1 | ACAT1 | ncbigene_symbol | ACAT1 | 38 |
| Homo sapiens | Primates | ACAT1 | ACAT1 | ncbigene_synonym | SOAT1 | 6646 |
| Homo sapiens | Primates | ACAT1/2 | ACAT2 | ncbigene_symbol | ACAT2 | 39 |
| Homo sapiens | Primates | ACAT1/2 | ACAT2 | ncbigene_synonym | SOAT2 | 8435 |
| Homo sapiens | Primates | DGAT1 | DGAT1 | ncbigene_symbol | DGAT1 | 8694 |
| Homo sapiens | Primates | DGAT1/2 | DGAT2 | ncbigene_symbol | DGAT2 | 84649 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| CPLA | NA | mesh:C028386 | ||
| Prostaglandins | prostaglandin | mesh:D011453 | Prostaglandins | chebi:26333 |
| Thromboxanes | Thromboxanes | mesh:D013931 | thromboxane | chebi:26995 |
| Leukotrienes | Leukotrienes | mesh:D015289 | leukotriene | chebi:25029 |
| Arachidonoyl | NA | mesh:C026563 | ||
| 4-COA Fatty Acyl-CoA | NA | mesh:D000214 | ||
| EETS,Endocannabinoids | Endocannabinoids | mesh:D063388 | endocannabinoid | chebi:67197 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|---|---|---|---|
| LPIAT | NA |