ADAR1-mediated RNA editing in cancer development

ADAR1-mediated RNA editing in cancer development. The color of the first arrow in each pathway indicates the mechanism (refer to Figure ) by which ADAR1 regulates its direct targets, depicted in pink icons or shapes. Dashed lines indicate suggested/unproven functions/relationships. Additional activators and inhibitors of specific pathway steps are depicted in red and yellow rounded rectangles, respectively. Specific diseases and phenotypes/functions affected by ADAR1-mediated RNA editing are only labeled in the first appearance (ex. proliferation…etc). HCC, hepatocellular carcinoma; ESCC, esophageal squamous cell carcinoma; CRC, colorectal cancer; BC, breast cancer; CC, cervical cancer; OC, ovarian cancer; MM, multiple myeloma; MB, medulloblastoma; BCC, basal cell carcinoma; CML, chronic myeloid leukemia; PC, prostate cancer; LUAD, lung adenocarcinoma; KC, kidney cancer; BLC, bladder cancer. The figure was created with BioRender.
ADAR1-mediated RNA editing in cancer development
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Publication

The Role of RNA Editing in Cancer Development and Metabolic Disorders. (2018) Che-Pei Kung, et al. Front Endocrinol (Lausanne). 2018;9:762. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates ODC ODC ncbigene_synonym ODC1 4953
Homo sapiens Primates ODC ODC ncbigene_synonym SLC25A21 89874
Homo sapiens Primates (HCC/ESCCICRC/BC) HCC ncbigene_symbol HCC 619501
Homo sapiens Primates (HCC/ESCCICRC/BC) HCC ncbigene_synonym HYCC1 84668
Homo sapiens Primates AZIN1 AZIN1 ncbigene_symbol AZIN1 51582
Homo sapiens Primates STAT3 STAT3 ncbigene_symbol STAT3 6774
Homo sapiens Primates (cc) CC ncbigene_synonym CXCR1 3577
Homo sapiens Primates BLCAP BLCAP ncbigene_symbol BLCAP 10904
Homo sapiens Primates GABRA3 GABRA3 ncbigene_symbol GABRA3 2556
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates CD8: CD8 ncbigene_synonym CD8A 925
Homo sapiens Primates CD8: CD8 famplex_relations CD8B 926
Homo sapiens Primates CCNI CCNI ncbigene_symbol CCNI 10983
Homo sapiens Primates SUFU SUFU ncbigene_symbol SUFU 51684
Homo sapiens Primates GLI1 GLI1 ncbigene_symbol GLI1 2735
Homo sapiens Primates Hedgehog HEDGEHOG famplex_relations DHH 50846
Homo sapiens Primates Hedgehog HEDGEHOG famplex_relations IHH 3549
Homo sapiens Primates Hedgehog HEDGEHOG famplex_relations SHH 6469
Homo sapiens Primates (MB/BCC) MB ncbigene_symbol MB 4151
Homo sapiens Primates ADAR1 ADAR1 ncbigene_synonym ADAR 103
Homo sapiens Primates CPEB1 CPEB1 ncbigene_symbol CPEB1 64506
Homo sapiens Primates CREB CREB ncbigene_synonym CREB1 1385
Homo sapiens Primates CREB CREB famplex_relations CREB3 10488
Homo sapiens Primates CREB CREB famplex_relations CREB5 9586
Homo sapiens Primates CREB CREB famplex_relations CREB3L1 90993
Homo sapiens Primates CREB CREB famplex_relations CREB3L2 64764
Homo sapiens Primates CREB CREB famplex_relations CREB3L3 84699
Homo sapiens Primates CREB CREB famplex_relations CREB3L4 148327
Homo sapiens Primates CREB CREB famplex_relations CREM 1390
Homo sapiens Primates CREB CREB famplex_relations ATF1 466
Homo sapiens Primates CREB CREB famplex_relations ATF2 1386
Homo sapiens Primates DHFR DHFR ncbigene_symbol DHFR 1719
Homo sapiens Primates LSC LSC ncbigene_synonym ARHGEF1 9138
Homo sapiens Primates (CML) CML ncbigene_synonym BCR 613
Homo sapiens Primates LIN28 LIN28 ncbigene_synonym LIN28A 79727
Homo sapiens Primates PCA3 PCA3 ncbigene_symbol PCA3 50652
Homo sapiens Primates (PC) PC ncbigene_symbol PC 5091
Homo sapiens Primates PRUNE2 PRUNE2 ncbigene_symbol PRUNE2 158471
Homo sapiens Primates FAK FAK ncbigene_synonym PTK2 5747
Homo sapiens Primates HNRPLL HNRPLL ncbigene_synonym HNRNPLL 92906
Homo sapiens Primates TGFBR1 TGFBR1 ncbigene_symbol TGFBR1 7046
Homo sapiens Primates (KC/BLC) BLC ncbigene_synonym CXCL13 10563
Homo sapiens Primates RSF1 RSF1 ncbigene_symbol RSF1 51773
Homo sapiens Primates ADAR2 ADAR2 ncbigene_synonym ADARB1 104
Homo sapiens Primates TH TH ncbigene_symbol TH 7054
Homo sapiens Primates CNI CNI ncbigene_synonym NT5C1A 84618
Mus musculus Rodents ODC ODC ncbigene_synonym Odc1 18263
Mus musculus Rodents AZIN1 AZIN1 ncbigene_symbol Azin1 54375
Mus musculus Rodents Antizyme ANTIZYME ncbigene_synonym Oaz1 18245
Mus musculus Rodents STAT3 STAT3 ncbigene_symbol Stat3 20848
Mus musculus Rodents (cc) CC ncbigene_synonym Ccr8 12776
Mus musculus Rodents BLCAP BLCAP ncbigene_symbol Blcap 53619
Mus musculus Rodents GABRA3 GABRA3 ncbigene_symbol Gabra3 14396
Mus musculus Rodents AKT AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents CCNI CCNI ncbigene_symbol Ccni 12453
Mus musculus Rodents SUFU SUFU ncbigene_symbol Sufu 24069
Mus musculus Rodents GLI1 GLI1 ncbigene_symbol Gli1 14632
Mus musculus Rodents (MB/BCC) MB ncbigene_symbol Mb 17189
Mus musculus Rodents ADAR1 ADAR1 ncbigene_synonym Adar 56417
Mus musculus Rodents CPEB1 CPEB1 ncbigene_symbol Cpeb1 12877
Mus musculus Rodents CREB CREB ncbigene_synonym Creb1 12912
Mus musculus Rodents DHFR DHFR ncbigene_symbol Dhfr 13361
Mus musculus Rodents LSC LSC ncbigene_synonym Arhgef1 16801
Mus musculus Rodents LIN28 LIN28 ncbigene_synonym Lin28a 83557
Mus musculus Rodents (PC) PC ncbigene_symbol pc 18517
Mus musculus Rodents PRUNE2 PRUNE2 ncbigene_symbol Prune2 353211
Mus musculus Rodents FAK FAK ncbigene_synonym Ptk2 14083
Mus musculus Rodents HNRPLL HNRPLL ncbigene_synonym Hnrnpll 72692
Mus musculus Rodents TGFBR1 TGFBR1 ncbigene_symbol Tgfbr1 21812
Mus musculus Rodents (KC/BLC) BLC ncbigene_synonym Cxcl13 55985
Mus musculus Rodents RSF1 RSF1 ncbigene_symbol Rsf1 233532
Mus musculus Rodents ADAR2 ADAR2 ncbigene_synonym Adarb1 110532
Mus musculus Rodents TH TH ncbigene_symbol Th 21823
Mus musculus Rodents It IT ncbigene_symbol It 103984
Rattus norvegicus Rodents ODC ODC ncbigene_synonym Odc1 24609
Rattus norvegicus Rodents AZIN1 AZIN1 ncbigene_symbol Azin1 58961
Rattus norvegicus Rodents STAT3 STAT3 ncbigene_symbol Stat3 25125
Rattus norvegicus Rodents BLCAP BLCAP ncbigene_symbol Blcap 171113
Rattus norvegicus Rodents GABRA3 GABRA3 ncbigene_symbol Gabra3 24947
Rattus norvegicus Rodents AKT AKT ncbigene_synonym Akt1 24185
Rattus norvegicus Rodents CCNI CCNI ncbigene_symbol Ccni 289500
Rattus norvegicus Rodents SUFU SUFU ncbigene_symbol Sufu 361769
Rattus norvegicus Rodents GLI1 GLI1 ncbigene_symbol Gli1 140589
Rattus norvegicus Rodents (MB/BCC) MB ncbigene_symbol Mb 59108
Rattus norvegicus Rodents CPEB1 CPEB1 ncbigene_symbol Cpeb1 293056
Rattus norvegicus Rodents CREB CREB ncbigene_synonym Creb1 81646
Rattus norvegicus Rodents DHFR DHFR ncbigene_symbol Dhfr 24312
Rattus norvegicus Rodents LSC LSC ncbigene_synonym Arhgef1 60323
Rattus norvegicus Rodents LIN28 LIN28 ncbigene_synonym Lin28c 298542
Rattus norvegicus Rodents LIN28 LIN28 ncbigene_synonym Lin28a 500562
Rattus norvegicus Rodents (PC) PC ncbigene_symbol Pc 25104
Rattus norvegicus Rodents PRUNE2 PRUNE2 ncbigene_symbol Prune2 293823
Rattus norvegicus Rodents FAK FAK ncbigene_synonym Ptk2 25614
Rattus norvegicus Rodents HNRPLL HNRPLL ncbigene_synonym Hnrnpll 313842
Rattus norvegicus Rodents TGFBR1 TGFBR1 ncbigene_symbol Tgfbr1 29591
Rattus norvegicus Rodents RSF1 RSF1 ncbigene_symbol Rsf1 308839
Rattus norvegicus Rodents ADAR2 ADAR2 ncbigene_synonym Adarb1 25367
Rattus norvegicus Rodents TH TH ncbigene_symbol Th 25085
Oryctolagus cuniculus Mammals AZIN1 AZIN1 ncbigene_symbol AZIN1 100338727
Oryctolagus cuniculus Mammals STAT3 STAT3 ncbigene_symbol STAT3 100348778
Oryctolagus cuniculus Mammals BLCAP BLCAP ncbigene_symbol BLCAP 100341338
Oryctolagus cuniculus Mammals GABRA3 GABRA3 ncbigene_symbol GABRA3 100349107
Oryctolagus cuniculus Mammals CCNI CCNI ncbigene_symbol CCNI 100351342
Oryctolagus cuniculus Mammals SUFU SUFU ncbigene_symbol SUFU 100345361
Oryctolagus cuniculus Mammals GLI1 GLI1 ncbigene_symbol GLI1 100358990
Oryctolagus cuniculus Mammals (MB/BCC) MB ncbigene_symbol MB 100351487
Oryctolagus cuniculus Mammals CPEB1 CPEB1 ncbigene_symbol CPEB1 100358916
Oryctolagus cuniculus Mammals DHFR DHFR ncbigene_symbol DHFR 100359209
Oryctolagus cuniculus Mammals (PC) PC ncbigene_symbol PC 127487948
Oryctolagus cuniculus Mammals PRUNE2 PRUNE2 ncbigene_symbol PRUNE2 100339950
Oryctolagus cuniculus Mammals HNRPLL HNRPLL ncbigene_synonym HNRNPLL 100338555
Oryctolagus cuniculus Mammals TGFBR1 TGFBR1 ncbigene_symbol TGFBR1 100345812
Oryctolagus cuniculus Mammals RSF1 RSF1 ncbigene_symbol RSF1 100350799
Oryctolagus cuniculus Mammals TH TH ncbigene_symbol TH 100009362
Drosophila melanogaster Invertebrates AKT AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates (BC/OC/melanoma) OC ncbigene_symbol oc 31802
Drosophila melanogaster Invertebrates SUFU SUFU ncbigene_synonym Su(fu) 41565
Drosophila melanogaster Invertebrates (MB/BCC) MB ncbigene_symbol mb 249737
Drosophila melanogaster Invertebrates (MB/BCC) MB ncbigene_synonym E(spl)mbeta-HLH 43152
Drosophila melanogaster Invertebrates ADAR1 ADAR1 ncbigene_synonym Adar 31130
Drosophila melanogaster Invertebrates DY DY ncbigene_symbol dy 32130
Drosophila melanogaster Invertebrates CREB CREB ncbigene_synonym CrebB 32817
Drosophila melanogaster Invertebrates CREB CREB ncbigene_synonym CrebA 39682
Drosophila melanogaster Invertebrates DHFR DHFR ncbigene_symbol Dhfr 42003
Drosophila melanogaster Invertebrates LSC LSC ncbigene_synonym l(1)sc 30983
Drosophila melanogaster Invertebrates let-7 LET-7 ncbigene_synonym lncRNA:let7C 12798010
Drosophila melanogaster Invertebrates let-7 LET-7 ncbigene_synonym mir-let7 12798012
Drosophila melanogaster Invertebrates (CML) CML ncbigene_symbol cml 248123
Drosophila melanogaster Invertebrates LIN28 LIN28 ncbigene_symbol lin-28 38639
Drosophila melanogaster Invertebrates (PC) PC ncbigene_symbol Pc 40358
Drosophila melanogaster Invertebrates FAK FAK ncbigene_symbol Fak 37233
Drosophila melanogaster Invertebrates (KC/BLC) BLC ncbigene_symbol blc 247878
Drosophila melanogaster Invertebrates RSF1 RSF1 ncbigene_symbol Rsf1 34370
Drosophila melanogaster Invertebrates RSF1 RSF1 ncbigene_synonym CG8677 35397
Drosophila melanogaster Invertebrates CNI CNI ncbigene_symbol cni 34967
Drosophila melanogaster Invertebrates РСАЗ PA ncbigene_symbol Pa 251550
Drosophila melanogaster Invertebrates It IT ncbigene_symbol I-t 41414
Danio rerio Vertebrates ODC ODC ncbigene_synonym odc1 114426
Danio rerio Vertebrates (HCC/ESCCICRC/BC) HCC ncbigene_synonym hccsa.2 101882578
Danio rerio Vertebrates AZIN1 AZIN1 ncbigene_synonym azin1b 317764
Danio rerio Vertebrates STAT3 STAT3 ncbigene_symbol stat3 30767
Danio rerio Vertebrates BLCAP BLCAP ncbigene_symbol blcap 57918
Danio rerio Vertebrates GABRA3 GABRA3 ncbigene_symbol gabra3 100538116
Danio rerio Vertebrates CCNI CCNI ncbigene_symbol ccni 406239
Danio rerio Vertebrates SUFU SUFU ncbigene_symbol sufu 100001615
Danio rerio Vertebrates GLI1 GLI1 ncbigene_symbol gli1 352930
Danio rerio Vertebrates (MB/BCC) MB ncbigene_symbol mb 393558
Danio rerio Vertebrates CPEB1 CPEB1 ncbigene_synonym cpeb1b 30702
Danio rerio Vertebrates DHFR DHFR ncbigene_symbol dhfr 81882
Danio rerio Vertebrates LIN28 LIN28 ncbigene_synonym lin28ab 394066
Danio rerio Vertebrates PRUNE2 PRUNE2 ncbigene_symbol prune2 556822
Danio rerio Vertebrates FAK FAK ncbigene_synonym ptk2ab 142986
Danio rerio Vertebrates TGFBR1 TGFBR1 ncbigene_synonym tgfbr1a 560578
Danio rerio Vertebrates ADAR2 ADAR2 ncbigene_synonym adarb1a 58134
Danio rerio Vertebrates TH TH ncbigene_symbol th 30384
Caenorhabditis elegans Invertebrates let-7 LET-7 ncbigene_symbol let-7 266952
Caenorhabditis elegans Invertebrates LIN28 LIN28 ncbigene_symbol lin-28 172626
Caenorhabditis elegans Invertebrates RSF1 RSF1 ncbigene_symbol rsf-1 174728
Xenopus laevis Vertebrates ODC ODC ncbigene_synonym odc1.L 379859
Xenopus laevis Vertebrates ODC ODC ncbigene_synonym odc1.S 108718243
Xenopus laevis Vertebrates AZIN1 AZIN1 ncbigene_synonym azin1.L 447408
Xenopus laevis Vertebrates STAT3 STAT3 ncbigene_synonym stat3.L 779100
Xenopus laevis Vertebrates BLCAP BLCAP ncbigene_synonym blcap.L 734346
Xenopus laevis Vertebrates GABRA3 GABRA3 ncbigene_synonym gabra3.L 100653496
Xenopus laevis Vertebrates CD8: CD8 ncbigene_synonym cd8a.L 100653505
Xenopus laevis Vertebrates CD8: CD8 ncbigene_synonym cd8a.S 108706508
Xenopus laevis Vertebrates CCNI CCNI ncbigene_synonym ccni.L 398997
Xenopus laevis Vertebrates CCNI CCNI ncbigene_synonym ccni.S 495823
Xenopus laevis Vertebrates SUFU SUFU ncbigene_synonym sufu.L 444442
Xenopus laevis Vertebrates GLI1 GLI1 ncbigene_synonym gli1.S 398350
Xenopus laevis Vertebrates GLI1 GLI1 ncbigene_synonym gli1.L 108708587
Xenopus laevis Vertebrates Hedgehog HEDGEHOG ncbigene_synonym shh.L 398047
Xenopus laevis Vertebrates Hedgehog HEDGEHOG ncbigene_synonym shh.S 108719826
Xenopus laevis Vertebrates ADAR1 ADAR1 ncbigene_synonym adar.S 397992
Xenopus laevis Vertebrates CPEB1 CPEB1 ncbigene_synonym cpeb1.L 399289
Xenopus laevis Vertebrates CPEB1 CPEB1 ncbigene_synonym cpeb1.S 734470
Xenopus laevis Vertebrates CREB CREB ncbigene_synonym creb1.S 379764
Xenopus laevis Vertebrates CREB CREB ncbigene_synonym creb1.L 108701473
Xenopus laevis Vertebrates DHFR DHFR ncbigene_synonym dhfr.L 495375
Xenopus laevis Vertebrates (CML) CML ncbigene_synonym bcr.L 431900
Xenopus laevis Vertebrates (CML) CML ncbigene_synonym bcr.S 108707115
Xenopus laevis Vertebrates (CML) CML ncbigene_synonym nat8.6.L 108719408
Xenopus laevis Vertebrates LIN28 LIN28 ncbigene_synonym lin28b.S 373796
Xenopus laevis Vertebrates LIN28 LIN28 ncbigene_synonym lin28a.S 387262
Xenopus laevis Vertebrates LIN28 LIN28 ncbigene_synonym lin28a.L 108708102
Xenopus laevis Vertebrates LIN28 LIN28 ncbigene_synonym lin28b.L 108716855
Xenopus laevis Vertebrates FAK FAK ncbigene_synonym ptk2.L 399286
Xenopus laevis Vertebrates FAK FAK ncbigene_synonym ptk2.S 432072
Xenopus laevis Vertebrates TGFBR1 TGFBR1 ncbigene_synonym tgfbr1.S 399295
Xenopus laevis Vertebrates RSF1 RSF1 ncbigene_synonym rsf1.S 446248

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
tumor NA mesh:D009369
melanoma NA mesh:D008545
CML NA mesh:D015464