Branched-chain amino acid (BCAA) biosynthetic pathway
Branched-chain amino acid (BCAA) biosynthetic pathway. Acetolactate synthase (ALS) catalyzes the first step of biosynthesis of BCAAs. Imazamox blocks the synthesis of valine, leucine, and isoleucine by inactivating the ALS enzyme [].
Publication
An imazamox-based herbicide causes apoptotic changes in rat liver and pancreas. (2019) Çiğdem Sevim, et al. Toxicol Rep. 2019;6:42-50. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Threonine | Gly-Thr | mesh:C061951 | glycyl-threonine | chebi:73920 |
| 2-Aminobutyrate | NA | mesh:D000613 | ||
| TPP | Thiamine Pyrophosphate | mesh:D013835 | thiamine(1+) diphosphate chloride | chebi:18290 |
| 2-Ketobutyrate | NA | mesh:C005087 | ||
| Pyruvate | NA | mesh:D011773 | ||
| aldehyde | Aldehydes | mesh:D000447 | aldehyde | chebi:17478 |
| FAD | Flavin-Adenine Dinucleotide | mesh:D005182 | FAD | chebi:16238 |
| Mg++ | Magnesium | mesh:D008274 | magnesium atom | chebi:25107 |
| Acetolactate | NA | mesh:C006359 | ||
| Norvaline | NA | mesh:C575978 | ||
| Norleucine | NA | mesh:C031684 | ||
| 2-Aceto-2-hydroxybutyrate | NA | mesh:C027745 | ||
| 2-Acetolactate | NA | mesh:C006359 | ||
| 2,3-Dihydroxy-3-methylvalerate | 3-methylvaleric acid | mesh:C042993 | 3-methylvaleric acid | chebi:166883 |
| 2,3-Dihydroxyisovalerate | NA | mesh:C039620 | ||
| 2-Keto-3-methylvalerate | NA | mesh:C021047 | ||
| 2-Ketoisovalerate | NA | mesh:C001505 | ||
| Isoleucine | NA | mesh:C043801 | ||
| Valine | NA | mesh:C521924 | ||
| Leucine | NA | mesh:C038361 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|