Hypoxia induces differentiation of T-cells to Tregs

Hypoxia induces differentiation of T-cells to Tregs. T cells directly promote the expression of Foxp3 through the HIF signaling pathway. T cells promote the expression of TGF-β through HIF signaling, inhibit the key enzyme PHD2 for HIF-1α degradation, and indirectly promote the expression of Foxp3. Tumor cells promote the expression of TGF-β through the HIF signaling pathway, act on the receptors on the surface of T cells, activate the downstream SMAD signaling pathway, and promote the expression of Foxp3.Tumor cells promote the expression of PD-L1 on the cell surface through the HIF signaling pathway, bind PD-1 on the surface of T cells, inhibit the downstream AKT and mTOR pathways, and promote the expression of Foxp3
Hypoxia induces differentiation of T-cells to Tregs
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Publication

Effects of tumor metabolic microenvironment on regulatory T cells. (2018) Yi-an Wang, et al. Mol Cancer. 2018;17:168. Figure: F6.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates TGF-B TGFB ncbigene_synonym TGFB1 7040
Homo sapiens Primates TGF-B TGFB famplex_relations TGFB2 7042
Homo sapiens Primates TGF-B TGFB famplex_relations TGFB3 7043
Homo sapiens Primates HIF-1 HIF-1 ncbigene_synonym SETD2 29072
Homo sapiens Primates HIF-1a HIF-1A ncbigene_synonym HIF1A 3091
Homo sapiens Primates HIF-1B HIF-1B ncbigene_synonym ARNT 405
Homo sapiens Primates PD-L1 PD-L1 ncbigene_synonym CD274 29126
Homo sapiens Primates PD-1 PD-1 ncbigene_synonym PDCD1 5133
Homo sapiens Primates PD-1 PD-1 ncbigene_synonym RPL17 6139
Homo sapiens Primates PD-1 PD-1 ncbigene_synonym RPL17-C18orf32 100526842
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates MTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates SMAD3 SMAD3 ncbigene_symbol SMAD3 4088
Homo sapiens Primates SMAD4 SMAD4 ncbigene_symbol SMAD4 4089
Homo sapiens Primates SMAD SMAD famplex_relations SMAD1 4086
Homo sapiens Primates SMAD SMAD famplex_relations SMAD5 4090
Homo sapiens Primates SMAD SMAD famplex_relations SMAD6 4091
Homo sapiens Primates SMAD SMAD famplex_relations SMAD7 4092
Homo sapiens Primates SMAD SMAD famplex_relations SMAD9 4093
Homo sapiens Primates SMAD SMAD famplex_relations SMAD2 4087
Homo sapiens Primates Foxp3 FOXP3 ncbigene_symbol FOXP3 50943
Homo sapiens Primates PHD2 PHD2 ncbigene_synonym EGLN1 54583

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
HIF-1a HIF-1B NA mesh:C565748
HIF-1a NA mesh:C536041