NLRP3 priming following TLR activation

NLRP3 priming.Notes: Several pathways successively control NLRP3 priming following TLR activation. The early and intermediate non-transcriptional pathways are independent of de novo protein synthesis and rely on post-translational modifications. They are, respectively, engaged by the MyD88 and the TRIF adaptors. Prolonged TLR or cytokine receptor activation prime NLRP3 through NF-κB-dependent transcriptional upregulation of NLRP3 and putative other factors. Both MyD88- and TRIF-dependent signaling drives this late transcriptional priming. All priming pathways depend on mitochondrial ROS.Abbreviations: TLR, Toll-like receptor; ROS, reactive oxygen species; LPS, lipopolysaccharide.
NLRP3 priming following TLR activation
Download JPG
View figure at PMC Read paper at PMC Open at NDEx
PMC
NDEx

Publication

Spotlight on the NLRP3 inflammasome pathway. (2018) Marine Groslambert, et al. J Inflamm Res. 2018;11:359-374. Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates min-1 MIN1 ncbigene_synonym CD59 966
Homo sapiens Primates LPS LPS ncbigene_synonym IRF6 3664
Homo sapiens Primates TLR4 TLR4 ncbigene_symbol TLR4 7099
Homo sapiens Primates TLR2 TLR2 ncbigene_symbol TLR2 7097
Homo sapiens Primates TLR3 TLR3 ncbigene_symbol TLR3 7098
Homo sapiens Primates MYD88 MYD88 ncbigene_symbol MYD88 4615
Homo sapiens Primates TRIF TRIF ncbigene_synonym TRIM69 140691
Homo sapiens Primates TRIF TRIF ncbigene_synonym TICAM1 148022
Homo sapiens Primates IRAK4 IRAK4 ncbigene_symbol IRAK4 51135
Homo sapiens Primates IRAK1 IRAK1 ncbigene_symbol IRAK1 3654
Homo sapiens Primates FADD FADD ncbigene_symbol FADD 8772
Homo sapiens Primates RIP1 RIP1 ncbigene_synonym UQCRFS1 7386
Homo sapiens Primates RIP1 RIP1 ncbigene_synonym RIPK1 8737
Homo sapiens Primates RIP1 RIP1 ncbigene_synonym RALBP1 10928
Homo sapiens Primates RIP1 RIP1 ncbigene_synonym KRR1 11103
Homo sapiens Primates NF-KB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates NLRP3 NLRP3 ncbigene_symbol NLRP3 114548
Mus musculus Rodents min MIN ncbigene_synonym Apc 11789
Mus musculus Rodents LPS LPS ncbigene_synonym Tlr4 21898
Mus musculus Rodents TLR2 TLR2 ncbigene_symbol Tlr2 24088
Mus musculus Rodents TLR3 TLR3 ncbigene_symbol Tlr3 142980
Mus musculus Rodents MYD88 MYD88 ncbigene_symbol Myd88 17874
Mus musculus Rodents TRIF TRIF ncbigene_synonym Rnf138 56515
Mus musculus Rodents TRIF TRIF ncbigene_synonym Trim69 70928
Mus musculus Rodents TRIF TRIF ncbigene_synonym Ticam1 106759
Mus musculus Rodents TRIF TRIF ncbigene_synonym Ticam2 225471
Mus musculus Rodents IRAK4 IRAK4 ncbigene_symbol Irak4 266632
Mus musculus Rodents IRAK1 IRAK1 ncbigene_symbol Irak1 16179
Mus musculus Rodents FADD FADD ncbigene_symbol Fadd 14082
Mus musculus Rodents RIP1 RIP1 ncbigene_synonym Ralbp1 19765
Mus musculus Rodents RIP1 RIP1 ncbigene_synonym Ripk1 19766
Mus musculus Rodents NF-KB NF-KB ncbigene_synonym Nfkb1 18033
Mus musculus Rodents NLRP3 NLRP3 ncbigene_symbol Nlrp3 216799
Danio rerio Vertebrates TLR2 TLR2 ncbigene_symbol tlr2 403125
Danio rerio Vertebrates TLR3 TLR3 ncbigene_symbol tlr3 403126
Danio rerio Vertebrates MYD88 MYD88 ncbigene_symbol myd88 403145
Danio rerio Vertebrates TRIF TRIF ncbigene_synonym ticam1 403147
Danio rerio Vertebrates IRAK4 IRAK4 ncbigene_symbol irak4 393132
Danio rerio Vertebrates IRAK1 IRAK1 ncbigene_symbol irak1 569226
Danio rerio Vertebrates FADD FADD ncbigene_symbol fadd 562317
Danio rerio Vertebrates Caspase-8 CASPASE-8 ncbigene_synonym casp8 58022
Danio rerio Vertebrates RIP1 RIP1 ncbigene_synonym ripk1l 567460
Danio rerio Vertebrates NLRP3 NLRP3 ncbigene_symbol nlrp3 567964

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID