JAK-STAT signaling in tandem with multiple cytokines and hormones participates in the regulation of Beta-cells

JAK-STAT signaling in tandem with multiple cytokines and hormones participates in the regulation of β-cells. Circles of the same color represent signals within the same pathway. Red and black lines indicate inhibition and promotion, respectively. JAK-STAT, janus kinase-signal transducers and activators of transcription; EPO, erythropoietin; GH, growth hormone; PRL, prolactin; FOXM1, forkhead box protein M1; cdk, cyclin-dependent kinase; SOCS, suppressor of cytokine signaling; CISH, cytokine-inducible SH2 domain-containing proteins; IFN-γ, interferon-γ; IFN-γR, interferon-γ receptor; IL-6, interleukin 6; IL-6R, interleukin 6 receptor; PKB, protein kinase B; MAPK, mitogen-activated protein kinase; mTORC1, mechanistic target of rapamycin complex 1; Ras, rat sarcomas; P, phosphorylated.

Publication

Cellular signaling pathways regulating β-cell proliferation as a promising therapeutic target in the treatment of diabetes. (2018) Wen-Juan Jiang, et al. Exp Ther Med. 2018 Oct;16(4):3275-3285. Figure: F3. All organisms Mus musculus Rattus norvegicus Gallus gallus Homo sapiens Danio rerio

Disease mentions