Schematic view of MHC class I (MHC-I) pathways of antigen processing and presentation

Schematic view of MHC class I (MHC-I) pathways of antigen processing and presentation. Proteins in the cytosol engage the proteasome (1) and the peptides generated (2) are transported through the TAP1/2 transporter to the endoplasmic reticulum (ER). Partially folded MHC-I/β2-microgolobulin (β2m) complexes (3) are stabilized as part of the peptide loading complex (PLC) (4) where they may be retained in a peptide-receptive state. Once high affinity peptide is bound, the peptide/MHC-I (5) is released from the PLC and destined for the secretory pathway and the cell surface (6). Alternatively, partially folded MHC-I/β2m complexes (3) are stabilized by interaction with TAP-binding protein, related (TAPBPR) (7), loaded with peptide, released from TAPBPR (8), and the assembled MHC-I proceeds to the cell surface (9). Not illustrated are the peptide trimming enzymes (ERAAP or ERAP1/2) or the quality control UGGT1 interaction as described in the text.

Publication

The Role of Molecular Flexibility in Antigen Presentation and T Cell Receptor-Mediated Signaling. (2018) Kannan Natarajan, et al. Front Immunol. 2018;9:1657. Figure: F1. All organisms Mus musculus Danio rerio

Disease mentions