Proteasome Inhibitors: Structure and Function

Proteasome inhibition acts through multiple mechanisms to induce cell death. Inhibition of NF-κB results in downregulation of multiple pro-neoplastic pathways. Activation of the JNK pathway leads to caspase activation and apoptosis. Additionally, interference with the degradation of pro-apoptotic proteins such as Bim, BIK, BID, or Bax and an increase in NOXA activation promotes apoptosis. The depletion of ubiquitin and ER stress with activation of the unfolded protein response can promote apoptosis as well.
Proteasome Inhibitors: Structure and Function
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Publication

Proteasome Inhibitors: Structure and Function. (2017) Ana T. Nunes, et al. Semin Oncol. 2017 Dec;44(6):377-380. Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates (JNK) JNK ncbigene_synonym MAPK8 5599
Homo sapiens Primates (JNK) JNK famplex_relations MAPK9 5601
Homo sapiens Primates (JNK) JNK famplex_relations MAPK10 5602
Homo sapiens Primates Jun JUN ncbigene_symbol JUN 3725
Homo sapiens Primates Jun JUN famplex_relations JUNB 3726
Homo sapiens Primates Jun JUN famplex_relations JUND 3727
Homo sapiens Primates NOXA NOXA ncbigene_synonym PMAIP1 5366
Homo sapiens Primates p53 P53 ncbigene_synonym TP53 7157
Homo sapiens Primates p53 P53 famplex_relations TP63 8626
Homo sapiens Primates p53 P53 famplex_relations TP73 7161
Homo sapiens Primates Caspase CASPASE famplex_relations CASP1 834
Homo sapiens Primates Caspase CASPASE famplex_relations CASP2 835
Homo sapiens Primates Caspase CASPASE famplex_relations CASP4 837
Homo sapiens Primates Caspase CASPASE famplex_relations CASP5 838
Homo sapiens Primates Caspase CASPASE famplex_relations CASP6 839
Homo sapiens Primates Caspase CASPASE famplex_relations CASP8 841
Homo sapiens Primates Caspase CASPASE famplex_relations CASP9 842
Homo sapiens Primates Caspase CASPASE famplex_relations CASP10 843
Homo sapiens Primates Caspase CASPASE famplex_relations CASP12 100506742
Homo sapiens Primates Caspase CASPASE famplex_relations CASP14 23581
Homo sapiens Primates Caspase CASPASE famplex_relations CASP3 836
Homo sapiens Primates Caspase CASPASE famplex_relations CASP7 840
Homo sapiens Primates NF-KB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA1 5682
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA2 5683
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA3 5684
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA4 5685
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA5 5686
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA6 5687
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA7 5688
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA8 143471
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB1 5689
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB10 5699
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB2 5690
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB3 5691
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB4 5692
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB5 5693
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB6 5694
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB7 5695
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB8 5696
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB9 5698
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC1 5700
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC2 5701
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC3 5702
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC4 5704
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC5 5705
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC6 5706
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD1 5707
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD10 5716
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD11 5717
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD12 5718
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD13 5719
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD14 10213
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD2 5708
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD3 5709
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD4 5710
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD5 5711
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD6 9861
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD7 5713
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD8 5714
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD9 5715
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSME1 5720
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSME2 5721
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSME3 10197
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMF1 9491
Homo sapiens Primates Proteasome PROTEASOME famplex_relations SEM1 7979
Homo sapiens Primates Proteasome PROTEASOME famplex_relations USP5 8078
Homo sapiens Primates Bim BIM ncbigene_synonym BCL2L11 10018
Homo sapiens Primates BIK BIK ncbigene_symbol BIK 638
Homo sapiens Primates BID BID ncbigene_symbol BID 637
Danio rerio Vertebrates ubiquitin UBIQUITIN ncbigene_synonym tmub2 368511
Danio rerio Vertebrates ubiquitin UBIQUITIN ncbigene_synonym nedd8 368667
Danio rerio Vertebrates kinase KINASE ncbigene_synonym pak2a 266749
Danio rerio Vertebrates kinase KINASE ncbigene_synonym itpka 368717
Danio rerio Vertebrates (JNK) JNK ncbigene_synonym mapk8b 65236
Danio rerio Vertebrates Jun JUN ncbigene_symbol jun 335916
Danio rerio Vertebrates p53 P53 ncbigene_synonym tp53 30590
Danio rerio Vertebrates Bim BIM ncbigene_synonym bcl2l11 100190951
Danio rerio Vertebrates BIK BIK ncbigene_symbol bik 564030
Danio rerio Vertebrates BIK BIK ncbigene_synonym bhik 114357
Danio rerio Vertebrates BID BID ncbigene_synonym bida 559425

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID