The p53-p21 pathway inhibits ferroptosis during metabolic stress

Ferroptosis is an oxidative, non-apoptotic form of cell death that can be triggered by deprivation of cystine. Cystine is imported into the cell where it is reduced to the amino acid cysteine. Cysteine is necessary for the synthesis of the tripeptide antioxidant, glutathione, which is used by the lipid hydroperoxidase GPX4 to suppress the accumulation of lipid reactive oxygen species (ROS, red stars). Stabilization of p53 leads to increased expression of p21CIP1/WAF1 (p21). p21 promotes the conservation of glutathione during ferroptosis to suppress the formation of lipid ROS and prolong cell survival.
The p53-p21 pathway inhibits ferroptosis during metabolic stress
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Publication

The p53-p21 pathway inhibits ferroptosis during metabolic stress. (2018) Amy Tarangelo, et al. Oncotarget. 2018 May 15;9(37):24572-24573. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents (p21 P21 ncbigene_synonym Cdkn1a 12575
Mus musculus Rodents (p21 P21 ncbigene_synonym Nsg1 18196
Mus musculus Rodents (p21 P21 ncbigene_synonym Tpt1 22070
Mus musculus Rodents (p21 P21 ncbigene_synonym Tceal1 237052
Mus musculus Rodents GPX4 GPX4 ncbigene_symbol Gpx4 625249
Mus musculus Rodents GPX4 GPX4 ncbigene_synonym Gpx4-ps2 664781
Mus musculus Rodents (p53) P53 ncbigene_synonym Trp53 22059
Homo sapiens Primates (p21 P21 ncbigene_synonym CDKN1A 1026
Homo sapiens Primates (p21 P21 ncbigene_synonym TCEAL1 9338
Homo sapiens Primates (p21 P21 ncbigene_synonym NSG1 27065
Homo sapiens Primates (p21 P21 ncbigene_synonym H3P16 644914
Homo sapiens Primates GPX4 GPX4 ncbigene_symbol GPX4 2879
Homo sapiens Primates (p53) P53 ncbigene_synonym TP53 7157
Homo sapiens Primates (p53) P53 famplex_relations TP63 8626
Homo sapiens Primates (p53) P53 famplex_relations TP73 7161

Chemical mentions

Word Match MeSH Name ChEBI
Cystine Cystine mesh:D003553 cystine chebi:17376
Glutamate NA
Cysteine Cysteine mesh:D003545 cysteine chebi:15356
Glycine Glycine mesh:D005998 glycine chebi:15428
Glutathione Glutathione mesh:D005978 glutathione chebi:16856

Disease mentions

Word Match MeSH Name DOID