NAD+ biosynthesis, consumption and salvage pathways

NAD+ biosynthesis, consumption and salvage pathways. The intracellular NAD+ pool consists of both oxidized (NAD+) and reduced (NADH) forms. Electrons derived from substrate catabolism are carried by NADH and used for oxidative phosphorylation and biosynthetic reactions. NAD+ also functions as a co-substrate for sirtuins, ADP-ribose transferases, and cyclic ADP-ribose synthases (CD38). Eukaryotes synthesize NAD+ from the amino acid tryptophan via the de novo pathway or NAD+ can be salvaged from nicotinamide (NAM) and converted into nicotinamide mononucleotide (NMN) by nicotinamide phosphoribosyltransferase (Nampt). NMN can also be generated by the phosphorylation of NR by nicotinamide riboside kinase (Nrk).
NAD+ biosynthesis, consumption and salvage pathways
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Publication

Raising NAD in heart failure: time to translate?. () Matthew A. Walker, et al. Circulation. ;137(21):2274-2277. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents CD38 CD38 ncbigene_symbol Cd38 12494
Mus musculus Rodents Nmnat1-3 NMNAT2 ncbigene_symbol Nmnat2 226518
Mus musculus Rodents Nmnat1-3 NMNAT1 ncbigene_symbol Nmnat1 66454
Mus musculus Rodents Nmnat1-3 NMNAT3 ncbigene_symbol Nmnat3 74080
Mus musculus Rodents Nampt NAMPT ncbigene_symbol Nampt 59027
Mus musculus Rodents NNMT NNMT ncbigene_symbol Nnmt 18113
Mus musculus Rodents NRK1,2 NRK1 ncbigene_synonym Nmrk1 225994
Mus musculus Rodents NRK NRK ncbigene_symbol Nrk 27206
Mus musculus Rodents (NR) NR ncbigene_symbol nr 18170
Homo sapiens Primates CD38 CD38 ncbigene_symbol CD38 952
Homo sapiens Primates Nmnat1-3 NMNAT2 ncbigene_symbol NMNAT2 23057
Homo sapiens Primates Nmnat1-3 NMNAT1 ncbigene_symbol NMNAT1 64802
Homo sapiens Primates Nmnat1-3 NMNAT3 ncbigene_symbol NMNAT3 349565
Homo sapiens Primates Nampt NAMPT ncbigene_symbol NAMPT 10135
Homo sapiens Primates (NAM) NAM ncbigene_synonym STAC3 246329
Homo sapiens Primates NNMT NNMT ncbigene_symbol NNMT 4837
Homo sapiens Primates NRK1,2 NRK1 ncbigene_synonym NMRK1 54981
Homo sapiens Primates NRK1,2 NRK2 ncbigene_synonym NEK4 6787
Homo sapiens Primates NRK1,2 NRK2 ncbigene_synonym NMRK2 27231
Homo sapiens Primates NRK NRK ncbigene_symbol NRK 203447
Rattus norvegicus Rodents CD38 CD38 ncbigene_symbol Cd38 25668
Rattus norvegicus Rodents Nmnat1-3 NMNAT2 ncbigene_symbol Nmnat2 289095
Rattus norvegicus Rodents Nmnat1-3 NMNAT1 ncbigene_symbol Nmnat1 298653
Rattus norvegicus Rodents Nmnat1-3 NMNAT3 ncbigene_symbol Nmnat3 363118
Rattus norvegicus Rodents Nampt NAMPT ncbigene_symbol Nampt 297508
Rattus norvegicus Rodents NNMT NNMT ncbigene_symbol Nnmt 300691
Rattus norvegicus Rodents NRK1,2 NRK1 ncbigene_synonym Nmrk1 499330
Rattus norvegicus Rodents NRK NRK ncbigene_symbol Nrk 315907
Drosophila melanogaster Invertebrates NADS NADS ncbigene_synonym Nadsyn 32328
Drosophila melanogaster Invertebrates Nmnat1-3 NMNAT1 ncbigene_synonym Nmnat 42987
Drosophila melanogaster Invertebrates De DE ncbigene_symbol de 248301
Drosophila melanogaster Invertebrates NRK NRK ncbigene_symbol Nrk 36445
Drosophila melanogaster Invertebrates (NR) NR ncbigene_symbol nr 5656957
Danio rerio Vertebrates Nmnat1-3 NMNAT2 ncbigene_symbol nmnat2 336257
Danio rerio Vertebrates Nmnat1-3 NMNAT1 ncbigene_symbol nmnat1 550322
Danio rerio Vertebrates Nmnat1-3 NMNAT3 ncbigene_symbol nmnat3 572070
Danio rerio Vertebrates NRK NRK ncbigene_synonym si:zfos-2326c3.2 561669

Chemical mentions

Word Match MeSH Name ChEBI
Nicotinic acid NA mesh:D009539
NADH NAD mesh:D009243 NAD(+) chebi:15846
NAD NAD mesh:D009243 NAD(+) chebi:15846
NADS NA mesh:C055737
Nicotinamide Niacinamide mesh:D009536 nicotinamide chebi:17154
Tryptophan NA
Nicotinamide Riboside N-ribosylnicotinamide mesh:C018613 nicotinamide-beta-riboside chebi:15927
Me4PY NA mesh:C525085

Disease mentions

Word Match MeSH Name DOID