UDP-GlcNAc and UDP-GalNAc biosynthetic pathways
Outline of the predicted and confirmed UDP-GlcNAc and UDP-GalNAc biosynthetic pathways. The chemical names within boxes are sugar compounds in these metabolic pathways. The enzymatic activity required for each step is shown within parentheses as a roman numeral. Arrows labeled a and b are the predicted reactions required for the construction of the distinct UDP-GalNAc biosynthetic pathway (shown on the left) and analyzed in this work. The dashed arrow labeled c indicates the known UDP-GalNAc biosynthetic pathway. The stippled background indicates the UDP-GalNAc biosynthetic pathway present in S. tokodaii identified in this study. Each cofactor used for each reaction is shown alongside the reaction. The ST designations indicate the protein catalyzing the corresponding reaction identified from S. tokodaii, and the underlined designations indicate the proteins characterized in this study.
Publication
Identification of a Direct Biosynthetic Pathway for UDP–N-Acetylgalactosamine from Glucosamine-6-Phosphate in Thermophilic Crenarchaeon Sulfolobus tokodaii. (2018) Mohammad Dadashipour, et al. J Bacteriol. 2018 May 15;200(10):e00048-18. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Drosophila melanogaster | Invertebrates | COA | COA | ncbigene_symbol | Coa | 248135 |
| Drosophila melanogaster | Invertebrates | (vii; | VII | ncbigene_synonym | ple | 38746 |
| Drosophila melanogaster | Invertebrates | (vii; | VII | ncbigene_synonym | Eig71Ee | 39706 |
| Drosophila melanogaster | Invertebrates | (vii; | VII | ncbigene_synonym | l(2)46Da | 47338 |
| Drosophila melanogaster | Invertebrates | (vii; | VII | ncbigene_synonym | anon-48Ae | 5657421 |
| Drosophila melanogaster | Invertebrates | (VI; | VI | ncbigene_symbol | vi | 250598 |
| Drosophila melanogaster | Invertebrates | (VI; | VI | ncbigene_synonym | Sh | 32780 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Fructose-6-P | Fructose | mesh:D005632 | fructose | chebi:28757 |
| glutamine | Arg-Gln | mesh:C578860 | arginyl-glutamine | chebi:73813 |
| glutamic acid | NA | mesh:C030030 | ||
| Galactosamine-6-P | Galactosamine | mesh:D005688 | 2-amino-2-deoxy-D-galactopyranose | chebi:60312 |
| Glucosamine-6-P | Glucosamine | mesh:D005944 | glucosamine | chebi:5417 |
| Acetyl-CoA | Acetyl Coenzyme A | mesh:D000105 | acetyl-CoA | chebi:15351 |
| Galactosamine | Galactosamine | mesh:D005688 | 2-amino-2-deoxy-D-galactopyranose | chebi:60312 |
| Glucosamine-1-P | Glucosamine | mesh:D005944 | glucosamine | chebi:5417 |
| GlcNAc-6-P | NA | mesh:C041162 | ||
| Acetyl | NA | mesh:C011632 | ||
| GalNAc-1-P | NA | mesh:C065803 | ||
| GlcNAc | NA | mesh:C097320 | ||
| UTP | Uridine Triphosphate | mesh:D014544 | UTP | chebi:15713 |
| UDP | Uridine Diphosphate | mesh:D014530 | UDP | chebi:17659 |
| GalNAc | NA | mesh:C065803 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|