Purine nucleotide biosynthesis
Purine nucleotide biosynthesis. The commonly occurring guanine nucleotide biosynthetic and salvage reactions are shown, as is the adenine nucleotide biosynthetic pathway. The IMPDH reaction is boxed. NK, nucleoside kinase; HPRT, hypoxanthine phosphoribosyl transferase; XPRT, xanthine phosphoribosyl transferase; GPRT, guanine phosphoribosyl transferase; GMPS, guanosine 5′-monophosphate synthetase; GMPR, guanosine 5′-monophosphate reductase; ADSS, adenylosuccinate synthetase; ADSL, adenylosuccinate lyase.
Publication
Fragment-Based Approach to Targeting Inosine-5′-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis. (2018) Ana Trapero, et al. J Med Chem. 2018 Apr 12;61(7):2806-2822. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Drosophila melanogaster | Invertebrates | ADSL | ADSL | ncbigene_symbol | AdSL | 42051 |
| Drosophila melanogaster | Invertebrates | AMP | AMP | ncbigene_synonym | Amph | 36383 |
| Drosophila melanogaster | Invertebrates | ADSS | ADSS | ncbigene_symbol | AdSS | 42466 |
| Drosophila melanogaster | Invertebrates | De | DE | ncbigene_symbol | de | 248301 |
| Drosophila melanogaster | Invertebrates | GMPS | GMPS | ncbigene_synonym | bur | 45830 |
| Drosophila melanogaster | Invertebrates | GMP | GMP | ncbigene_synonym | fliF | 45309 |
| Drosophila melanogaster | Invertebrates | HN- | HN | ncbigene_symbol | Hn | 38871 |
| Drosophila melanogaster | Invertebrates | IMPDH | IMPDH | ncbigene_synonym | ras | 43873 |
| Drosophila melanogaster | Invertebrates | IMP | IMP | ncbigene_symbol | Imp | 32009 |
| Drosophila melanogaster | Invertebrates | IMP | IMP | ncbigene_synonym | CG11110 | 37337 |
| Drosophila melanogaster | Invertebrates | IMP | IMP | ncbigene_synonym | CG17029 | 39740 |
| Drosophila melanogaster | Invertebrates | IMP | IMP | ncbigene_synonym | CG17028 | 39741 |
| Drosophila melanogaster | Invertebrates | IMP | IMP | ncbigene_synonym | CG17027 | 39742 |
| Drosophila melanogaster | Invertebrates | IMP | IMP | ncbigene_synonym | CG9391 | 40346 |
| Drosophila melanogaster | Invertebrates | IMP | IMP | ncbigene_synonym | CG9389 | 40347 |
| Homo sapiens | Primates | ADSL | ADSL | ncbigene_symbol | ADSL | 158 |
| Homo sapiens | Primates | AMP | AMP | ncbigene_synonym | APRT | 353 |
| Homo sapiens | Primates | AMP | AMP | ncbigene_synonym | MFAP1 | 4236 |
| Homo sapiens | Primates | ADSS | ADSS | ncbigene_synonym | ADSS2 | 159 |
| Homo sapiens | Primates | GMPS | GMPS | ncbigene_symbol | GMPS | 8833 |
| Homo sapiens | Primates | GMP | GMP | ncbigene_synonym | NT5C2 | 22978 |
| Homo sapiens | Primates | IMP | IMP | ncbigene_synonym | IMPA1 | 3612 |
| Homo sapiens | Primates | IMP | IMP | ncbigene_synonym | BRAP | 8315 |
| Homo sapiens | Primates | XMP | XMP | ncbigene_synonym | EMP2 | 2013 |
| Homo sapiens | Primates | HPRT | HPRT | ncbigene_synonym | HPRT1 | 3251 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Adenylosuccinate | NA | mesh:C012168 | ||
| AMP | adenosine 5'-monophosphate | mesh:D000249 | Adenosine Monophosphate | chebi:16027 |
| NAD | NAD | mesh:D009243 | NAD(+) | chebi:15846 |
| NADH | NAD | mesh:D009243 | NAD(+) | chebi:15846 |
| GMP | NA | mesh:C068152 | ||
| Guanosine | Guanosine | mesh:D006151 | guanosine | chebi:16750 |
| Inosine | Inosine | mesh:D007288 | inosine | chebi:17596 |
| Guanine | Guanine | mesh:D006147 | guanine | chebi:16235 |
| Nurokhanthine | NA | |||
| Xanthine | NA | mesh:D019820 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|