Schematic diagram for innate immune response against influenza A virus (IAV) infection

Schematic diagram for innate immune response against influenza A virus (IAV) infection. Intracellular detection of IAV infection by the host pathogen recognition receptors (PRRs) activates transcription factors nuclear factor kappa-light-chain-enhancer of activated B cells, interferon regulatory factor 3 (IRF3), and IRF7. The PRRs include retinoic acid-inducible gene-I protein, melanoma differentiation-associated gene 5, and toll-like receptors. Then these activated transcription factors trigger the expression of type I and type III interferons (IFNs). IFNs secreted by the infected cells interact with their receptors, which results in activation of Janus kinase-signal transducer and activator of transcription signaling pathway that governs the expression of various IFN-stimulated genes.
Schematic diagram for innate immune response against influenza A virus (IAV) infection
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Publication

Host Immune Response to Influenza A Virus Infection. (2018) Xiaoyong Chen, et al. Front Immunol. 2018;9:320. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates IFNR IFNR ncbigene_symbol IFNR 3466
Homo sapiens Primates IFNR IFNR ncbigene_synonym IFNAR2 3455
Homo sapiens Primates TYK2 TYK2 ncbigene_symbol TYK2 7297
Homo sapiens Primates MDA5 MDA5 ncbigene_synonym IFIH1 64135
Homo sapiens Primates RIG-I RIG-I ncbigene_synonym RIGI 23586
Homo sapiens Primates TRIF TRIF ncbigene_synonym TRIM69 140691
Homo sapiens Primates TRIF TRIF ncbigene_synonym TICAM1 148022
Homo sapiens Primates MYD88 MYD88 ncbigene_symbol MYD88 4615
Homo sapiens Primates TLR3 TLR3 ncbigene_symbol TLR3 7098
Homo sapiens Primates TLR7 TLR7 ncbigene_symbol TLR7 51284
Homo sapiens Primates MAVS MAVS ncbigene_symbol MAVS 57506
Homo sapiens Primates IRF3 IRF3 ncbigene_symbol IRF3 3661
Homo sapiens Primates IRF7 IRF7 ncbigene_symbol IRF7 3665
Homo sapiens Primates NF-KB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates IRF9 IRF9 ncbigene_symbol IRF9 10379
Homo sapiens Primates ISGF3 ISGF3 ncbigene_synonym STAT1 6772
Homo sapiens Primates ISGF3 ISGF3 ncbigene_synonym STAT2 6773
Homo sapiens Primates TRF3 TRF3 ncbigene_synonym TBPL2 387332
Homo sapiens Primates STAT STAT ncbigene_synonym SOAT1 6646
Homo sapiens Primates STAT STAT famplex_relations STAT3 6774
Homo sapiens Primates STAT STAT famplex_relations STAT4 6775
Homo sapiens Primates STAT STAT famplex_relations STAT6 6778
Homo sapiens Primates STAT STAT famplex_relations STAT5A 6776
Homo sapiens Primates STAT STAT famplex_relations STAT5B 6777
Mus musculus Rodents TYK2 TYK2 ncbigene_symbol Tyk2 54721
Mus musculus Rodents MDA5 MDA5 ncbigene_synonym Ifih1 71586
Mus musculus Rodents RIG-I RIG-I ncbigene_synonym Rigi 230073
Mus musculus Rodents TRIF TRIF ncbigene_synonym Rnf138 56515
Mus musculus Rodents TRIF TRIF ncbigene_synonym Trim69 70928
Mus musculus Rodents TRIF TRIF ncbigene_synonym Ticam1 106759
Mus musculus Rodents TRIF TRIF ncbigene_synonym Ticam2 225471
Mus musculus Rodents MYD88 MYD88 ncbigene_symbol Myd88 17874
Mus musculus Rodents TLR3 TLR3 ncbigene_symbol Tlr3 142980
Mus musculus Rodents TLR7 TLR7 ncbigene_symbol Tlr7 170743
Mus musculus Rodents MAVS MAVS ncbigene_symbol Mavs 228607
Mus musculus Rodents IRF3 IRF3 ncbigene_symbol Irf3 54131
Mus musculus Rodents IRF7 IRF7 ncbigene_symbol Irf7 54123
Mus musculus Rodents NF-KB NF-KB ncbigene_synonym Nfkb1 18033
Mus musculus Rodents IRF9 IRF9 ncbigene_symbol Irf9 16391
Mus musculus Rodents TRF3 TRF3 ncbigene_synonym Tbpl2 227606
Mus musculus Rodents STAT2 STAT2 ncbigene_symbol Stat2 20847
Sus scrofa Mammals TYK2 TYK2 ncbigene_symbol TYK2 397363
Sus scrofa Mammals MDA5 MDA5 ncbigene_synonym IFIH1 100101927
Sus scrofa Mammals RIG-I RIG-I ncbigene_synonym RIGI 396723
Sus scrofa Mammals MYD88 MYD88 ncbigene_symbol MYD88 396646
Sus scrofa Mammals TLR3 TLR3 ncbigene_symbol TLR3 100037937
Sus scrofa Mammals TLR7 TLR7 ncbigene_symbol TLR7 100037296
Sus scrofa Mammals TLR7 TLR7 ncbigene_synonym TLR8 397384
Sus scrofa Mammals MAVS MAVS ncbigene_symbol MAVS 100037290
Sus scrofa Mammals IRF3 IRF3 ncbigene_symbol IRF3 396656
Sus scrofa Mammals IRF7 IRF7 ncbigene_symbol IRF7 100037289
Sus scrofa Mammals IRF9 IRF9 ncbigene_symbol IRF9 780415
Sus scrofa Mammals STAT2 STAT2 ncbigene_symbol STAT2 396923
Zootoca vivipara Vertebrates TYK2 TYK2 ncbigene_symbol TYK2 118097506
Zootoca vivipara Vertebrates RIG-I RIGI ncbigene_symbol RIGI 118097520
Zootoca vivipara Vertebrates MYD88 MYD88 ncbigene_symbol MYD88 118092232
Zootoca vivipara Vertebrates TLR3 TLR3 ncbigene_symbol TLR3 118084174
Zootoca vivipara Vertebrates MAVS MAVS ncbigene_symbol MAVS 118079069
Zootoca vivipara Vertebrates IRF3 IRF3 ncbigene_symbol IRF3 118095336
Zootoca vivipara Vertebrates IRF7 IRF7 ncbigene_symbol IRF7 118088557
Zootoca vivipara Vertebrates IRF9 IRF9 ncbigene_symbol IRF9 118095209
Zootoca vivipara Vertebrates STAT2 STAT2 ncbigene_symbol STAT2 118079505
Anolis carolinensis Vertebrates TYK2 TYK2 ncbigene_symbol tyk2 100566727
Anolis carolinensis Vertebrates RIG-I RIGI ncbigene_symbol rigi 100565793
Anolis carolinensis Vertebrates MYD88 MYD88 ncbigene_symbol myd88 100561767
Anolis carolinensis Vertebrates TLR3 TLR3 ncbigene_symbol tlr3 100558018
Anolis carolinensis Vertebrates TLR7 TLR7 ncbigene_symbol tlr7 100563333
Anolis carolinensis Vertebrates IRF3 IRF3 ncbigene_symbol irf3 100561376
Anolis carolinensis Vertebrates IRF7 IRF7 ncbigene_symbol irf7 103278516
Anolis carolinensis Vertebrates STAT2 STAT2 ncbigene_symbol stat2 103277767
Danio rerio Vertebrates TYK2 TYK2 ncbigene_symbol tyk2 100536675
Danio rerio Vertebrates RIG-I RIG-I ncbigene_synonym rigi 100333797
Danio rerio Vertebrates TRIF TRIF ncbigene_synonym ticam1 403147
Danio rerio Vertebrates MYD88 MYD88 ncbigene_symbol myd88 403145
Danio rerio Vertebrates TLR3 TLR3 ncbigene_symbol tlr3 403126
Danio rerio Vertebrates TLR7 TLR7 ncbigene_symbol tlr7 100534776
Danio rerio Vertebrates MAVS MAVS ncbigene_symbol mavs 562867
Danio rerio Vertebrates IRF3 IRF3 ncbigene_symbol irf3 564854
Danio rerio Vertebrates IRF7 IRF7 ncbigene_symbol irf7 393650
Danio rerio Vertebrates IRF9 IRF9 ncbigene_symbol irf9 403013
Danio rerio Vertebrates TRF3 TRF3 ncbigene_synonym tbpl2 407713
Danio rerio Vertebrates STAT2 STAT2 ncbigene_symbol stat2 565200
Danio rerio Vertebrates STAT STAT ncbigene_synonym stat1b 368481
Danio rerio Vertebrates STAT STAT ncbigene_synonym stat4 368519

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID