The ADAM17/EGFR axis
The ADAM17/EGFR axis. The EGFR/ADAM17 positive feedback loop likely involves activation of ADAM17 via the EGFR/MAPK pathway and direct interaction of ERK1/2 with ADAM17. Additionally, by cleavage of Notch1 from a non-small lung carcinoma cell line ADAM17 regulates transcription of EGFR mRNA and increases EGFR expression on the cell surface, providing another mechanism contributing to positive feedback regulation.
Publication
The EGFR-ADAM17 Axis in Chronic Obstructive Pulmonary Disease and Cystic Fibrosis Lung Pathology. (2018) Marta Stolarczyk, et al. Mediators Inflamm. 2018;2018:1067134. Figure: F4.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | Notch1 | NOTCH1 | ncbigene_symbol | NOTCH1 | 4851 |
| Homo sapiens | Primates | ADAM17 | ADAM17 | ncbigene_symbol | ADAM17 | 6868 |
| Homo sapiens | Primates | AREG | AREG | ncbigene_symbol | AREG | 374 |
| Homo sapiens | Primates | EGFR | EGFR | ncbigene_symbol | EGFR | 1956 |
| Homo sapiens | Primates | MEK1 | MEK1 | ncbigene_synonym | MAP2K1 | 5604 |
| Homo sapiens | Primates | MEK1/2 | MEK2 | ncbigene_synonym | MAP2K2 | 5605 |
| Homo sapiens | Primates | ERK1 | ERK1 | ncbigene_synonym | MAPK3 | 5595 |
| Homo sapiens | Primates | ERK1/2 | ERK2 | ncbigene_synonym | MAPK1 | 5594 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|