GABA shunt metabolic pathway
GABA shunt metabolic pathway. GABA is first synthesized from its precursor glutamate via GAD catalysation, and it is then reversibly converted to SSA via GABA‐T catalysation. SSADH further catalyses the oxidation of SSA to succinate, which is an important component in the tricarboxylic acid (TCA) cycle. The mitochondrial transporters shown are GABA permease, a glutamate carrier and an aspartate–glutamate exchanger. SSA, succinic semialdehyde; GHB, γ‐hydroxybutyric acid; OAA, oxaloacetate; 2OG, 2‐oxoglutarate; TCA, tricarboxylic acid; and miETC, mitochondrial electron transport chain.
Publication
Multiplexed CRISPR/Cas9‐mediated metabolic engineering of γ‐aminobutyric acid levels in Solanum lycopersicum . (2018) Rui Li, et al. Plant Biotechnol J. 2018 Feb;16(2):415-427. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Drosophila melanogaster | Invertebrates | ŠSA | SSA | ncbigene_synonym | ss | 41988 |
| Drosophila melanogaster | Invertebrates | SA | SA | ncbigene_symbol | SA | 33974 |
| Drosophila melanogaster | Invertebrates | SA | SA | ncbigene_symbol | sa | 40367 |
| Drosophila melanogaster | Invertebrates | GABA | GABA | ncbigene_synonym | GABA-B-R1 | 34878 |
| Drosophila melanogaster | Invertebrates | GABA | GABA | ncbigene_synonym | Rdl | 39054 |
| Drosophila melanogaster | Invertebrates | GABA | GABA | ncbigene_synonym | Gabat | 40188 |
| Drosophila melanogaster | Invertebrates | (GAD | GAD | ncbigene_synonym | Gad1 | 38484 |
| Drosophila melanogaster | Invertebrates | (SSADH) | SSADH | ncbigene_symbol | Ssadh | 43092 |
| Drosophila melanogaster | Invertebrates | cycle, | CYCLE | ncbigene_synonym | CycE | 34924 |
| Drosophila melanogaster | Invertebrates | cycle, | CYCLE | ncbigene_synonym | cyc | 40162 |
| Homo sapiens | Primates | ŠSA | SSA | ncbigene_synonym | CALR | 811 |
| Homo sapiens | Primates | ŠSA | SSA | ncbigene_synonym | TRIM21 | 6737 |
| Homo sapiens | Primates | (GABA-T) | GABAT | ncbigene_synonym | ABAT | 18 |
| Homo sapiens | Primates | (GAD | GAD | ncbigene_synonym | GAD1 | 2571 |
| Homo sapiens | Primates | (GAD | GAD | famplex_relations | GAD2 | 2572 |
| Homo sapiens | Primates | (SSADH) | SSADH | ncbigene_synonym | ALDH5A1 | 7915 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Glyoxylate | Glyoxylates | mesh:D006038 | glyoxylates | chebi:51704 |
| GHB | NA | mesh:C079662 | ||
| Glutamate | NA | |||
| GABA | gamma-Aminobutyric Acid | mesh:D005680 | gamma-aminobutyric acid | chebi:16865 |
| Succinate | Succinates | mesh:D013386 | succinate | chebi:26806 |
| TCA | NA | mesh:C000589078 | ||
| Glu | Glu-Glu | mesh:C094686 | glutamyl-glutamic acid | chebi:5390 |
| Asp | Asp-Asp | mesh:C108952 | aspartyl-aspartic acid | chebi:73446 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
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