Schematic diagram of the CCL2/CCR2 axis activating Hh signaling
Schematic diagram of the CCL2/CCR2 axis activating Hh signaling. CCL2 triggers SMO and Gli-1 expression. Accumulated Gli-1 translocates to the nucleus, results in the activation of the EMT-related genes, leading to EMT and invasion of HCC cells. CCL2, chemokine (C-C motif) ligand 2; CCR2, C-C chemokine receptor type 2; Hh, Hedgehog; SMO, smoothened; EMT, epithelial-mesenchymal transition; HCC, hepatocellular carcinoma.
Publication
CCL2/CCR2 axis induces hepatocellular carcinoma invasion and epithelial-mesenchymal transition in vitro through activation of the Hedgehog pathway. (2018) Huijie Zhuang, et al. Oncol Rep. 2018 Jan;39(1):21-30. Figure: F7.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | SHH | SHH | ncbigene_symbol | SHH | 6469 |
| Homo sapiens | Primates | CCL-2 | CCL2 | ncbigene_symbol | CCL2 | 6347 |
| Homo sapiens | Primates | CCR2 | CCR2 | ncbigene_symbol | CCR2 | 729230 |
| Homo sapiens | Primates | Ptchl | PTCH1 | ncbigene_symbol | PTCH1 | 5727 |
| Homo sapiens | Primates | (SMO | SMO | ncbigene_symbol | SMO | 6608 |
| Homo sapiens | Primates | (SMO | SMO | ncbigene_synonym | SMOX | 54498 |
| Homo sapiens | Primates | Gli-1 | GLI1 | ncbigene_symbol | GLI1 | 2735 |
| Homo sapiens | Primates | EMT | EMT | ncbigene_synonym | ITK | 3702 |
| Homo sapiens | Primates | EMT | EMT | ncbigene_synonym | SLC22A3 | 6581 |
| Homo sapiens | Primates | Snail | SNAIL | ncbigene_synonym | SNAI1 | 6615 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|