The mevalonate pathway leads to cholesterol synthesis

The mevalonate pathway leads to cholesterol synthesis. Acetoacetyl CoA and acetyl CoA are converted to squalene, which is subsequently converted to cholesterol. Important enzymes in the pathway include 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR), farnesyl pyrophosphate synthase (FDPS), and farnesyl diphosphate farnesyltransferase 1 (FDFT1, also commonly called squalene synthase). Each of these enzymes can be inhibited by statins, bisphosphonates, and zaragozic acid, respectively; cholesterol can be depleted using methyl-β-cyclodextrin (MBCD).
The mevalonate pathway leads to cholesterol synthesis
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Publication

Inhibiting mevalonate pathway enzymes increases stromal cell resilience to a cholesterol-dependent cytolysin. (2017) Sholeem Griffin, et al. Sci Rep. 2017;7:17050. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Bos taurus Mammals HMG-COA HMGCOA ncbigene_synonym HMGCS2 503684
Bos taurus Mammals HMGCR HMGCR ncbigene_symbol HMGCR 407159
Bos taurus Mammals FDPS FDPS ncbigene_symbol FDPS 281156
Bos taurus Mammals FDFT1 FDFT1 ncbigene_symbol FDFT1 281767
Mus musculus Rodents HMGCR HMGCR ncbigene_symbol Hmgcr 15357
Mus musculus Rodents FDPS FDPS ncbigene_symbol Fdps 110196
Mus musculus Rodents FDFT1 FDFT1 ncbigene_symbol Fdft1 14137
Homo sapiens Primates HMGCR HMGCR ncbigene_symbol HMGCR 3156
Homo sapiens Primates FDPS FDPS ncbigene_symbol FDPS 2224
Homo sapiens Primates FDFT1 FDFT1 ncbigene_symbol FDFT1 2222
Equus caballus Mammals HMGCR HMGCR ncbigene_symbol HMGCR 100065577
Equus caballus Mammals FDPS FDPS ncbigene_symbol FDPS 100063641
Equus caballus Mammals FDFT1 FDFT1 ncbigene_symbol FDFT1 100060929

Chemical mentions

Word Match MeSH Name ChEBI
Acetoacetyl-CoA NA mesh:C010667
Cholesterol Cholesterol mesh:D002784 cholesterol chebi:16113
Bisphosphonates Diphosphonates mesh:D004164 1,1-bis(phosphonic acid) chebi:77383
Lanosterol Lanosterol mesh:D007810 lanosterol chebi:16521
Mevalonate NA mesh:D008798
Squalene Squalene mesh:D013185 squalene chebi:15440

Disease mentions

Word Match MeSH Name DOID