Chemical Inhibition of a Subset of Arabidopsis thaliana GSK3-like Kinases Activates Brassinosteroid Signaling

(A) Overview of the distribution of the 272 significant differentially regulated genes and their time dependency.(B) Activation of the BR signaling cascade (dashed arrows) triggered by binding of BRs to the membrane-localized BRI1 receptor. Through a still unknown mechanism, this signal is transported to the nucleus where it inhibits the BIN2 kinase. Bikinin acts by direct inhibition of the activity of the group II ASK family (red arrow). The inhibition of BIN2 kinase activity, either through an unknown signal after binding of BRs to the BRI1 receptor or after direct inhibition by bikinin, depletes the pool of phosphorylated BES1/BZR1 proteins. By the inhibition of BIN2 and the action of the BSU1 phosphatase, non-phosphorylated BES1/BZR1 proteins accumulate, which in turn activate the transcription of BR-related genes and the feedback inhibition on the BR biosynthesis.

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Chemical Inhibition of a Subset of Arabidopsis thaliana GSK3-like Kinases Activates Brassinosteroid Signaling. () Bert De Rybel, et al. Chem Biol. ;16(6):594-604. Figure: F6. All organisms Arabidopsis thaliana Drosophila melanogaster

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