Signaling Pathway and Dysregulation of PD1 and its Ligands in Lymphoid Malignancies

Tumor cells typically overexpress PD-L1 due to intrinsic factors (genetic alterations, activation of certain signaling pathways, and viral infection) and extrinsic factors (cytokines, such as IFN-γ, secreted by T cells attempting to destroy tumor cells). Interactions of tumor cell PD-L1 and PD-1 on immune cells of the tumor microenvironment (T cells and NK cells) induce immune cell exhaustion and result in failure to activate antitumor immunity.
Signaling Pathway and Dysregulation of PD1 and its Ligands in Lymphoid Malignancies
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Publication

Signaling Pathway and Dysregulation of PD1 and its Ligands in Lymphoid Malignancies. () Yi Xia, et al. Biochim Biophys Acta. ;1865(1):58-71. Figure: F4.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates APC APC ncbigene_symbol APC 324
Homo sapiens Primates APC APC ncbigene_synonym PROC 5624
Homo sapiens Primates MHC MHC ncbigene_synonym HLA-C 3107
Homo sapiens Primates ZAP-70 ZAP-70 ncbigene_synonym ZAP70 7535
Homo sapiens Primates CD3 CD3 famplex_relations CD247 919
Homo sapiens Primates CD3 CD3 famplex_relations CD3D 915
Homo sapiens Primates CD3 CD3 famplex_relations CD3E 916
Homo sapiens Primates CD3 CD3 famplex_relations CD3G 917
Homo sapiens Primates CD28 CD28 ncbigene_symbol CD28 940
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates CD80 CD80 ncbigene_symbol CD80 941
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates RAS RAS famplex_relations KRAS 3845
Homo sapiens Primates RAS RAS famplex_relations HRAS 3265
Homo sapiens Primates RAS RAS famplex_relations NRAS 4893
Homo sapiens Primates PD-L1 PD-L1 ncbigene_synonym CD274 29126
Homo sapiens Primates PD-1 PD-1 ncbigene_synonym PDCD1 5133
Homo sapiens Primates PD-1 PD-1 ncbigene_synonym RPL17 6139
Homo sapiens Primates PD-1 PD-1 ncbigene_synonym RPL17-C18orf32 100526842
Homo sapiens Primates SHP-1 SHP-1 ncbigene_synonym PTPN6 5777
Homo sapiens Primates SHP-2 SHP2 ncbigene_synonym PTPN11 5781
Homo sapiens Primates IFNY IFNG ncbigene_symbol IFNG 3458
Homo sapiens Primates AP1 AP1 ncbigene_synonym FOS 2353
Homo sapiens Primates AP1 AP1 ncbigene_synonym FOSB 2354
Homo sapiens Primates AP1 AP1 ncbigene_synonym JUN 3725
Homo sapiens Primates AP1 AP1 ncbigene_synonym JUNB 3726
Homo sapiens Primates AP1 AP1 ncbigene_synonym JUND 3727
Homo sapiens Primates AP1 AP1 famplex_relations FOSL1 8061
Homo sapiens Primates AP1 AP1 famplex_relations FOSL2 2355
Homo sapiens Primates otc.) OTC ncbigene_symbol OTC 5009
Homo sapiens Primates (STAT, STAT ncbigene_synonym SOAT1 6646
Homo sapiens Primates (STAT, STAT famplex_relations STAT1 6772
Homo sapiens Primates (STAT, STAT famplex_relations STAT2 6773
Homo sapiens Primates (STAT, STAT famplex_relations STAT3 6774
Homo sapiens Primates (STAT, STAT famplex_relations STAT4 6775
Homo sapiens Primates (STAT, STAT famplex_relations STAT6 6778
Homo sapiens Primates (STAT, STAT famplex_relations STAT5A 6776
Homo sapiens Primates (STAT, STAT famplex_relations STAT5B 6777
Drosophila melanogaster Invertebrates APC APC ncbigene_symbol Apc 44642
Drosophila melanogaster Invertebrates APC APC ncbigene_synonym Apc2 42871
Drosophila melanogaster Invertebrates APC APC ncbigene_synonym Axn 43565
Drosophila melanogaster Invertebrates APC APC ncbigene_synonym Fs(3)Apc 49116
Drosophila melanogaster Invertebrates MHC MHC ncbigene_symbol Mhc 35007
Drosophila melanogaster Invertebrates MHC MHC ncbigene_synonym zip 38001
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates AKT AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates RAS RAS ncbigene_symbol ras 43873
Drosophila melanogaster Invertebrates RAS RAS ncbigene_synonym Ras64B 38494
Drosophila melanogaster Invertebrates RAS RAS ncbigene_synonym Ras85D 41140
Drosophila melanogaster Invertebrates SHP-2 SHP-2 ncbigene_synonym csw 45278
Drosophila melanogaster Invertebrates Tur TUR ncbigene_symbol tur 44302
Drosophila melanogaster Invertebrates AP1 AP1 ncbigene_synonym AP-1gamma 31842
Drosophila melanogaster Invertebrates AP1 AP1 ncbigene_synonym Jra 36057
Drosophila melanogaster Invertebrates AP1 AP1 ncbigene_synonym kay 3772082
Drosophila melanogaster Invertebrates (STAT, STAT ncbigene_synonym Stat92E 42428
Arabidopsis thaliana Plants and Fungi PI3K PI3K ncbigene_synonym VPS34 842344
Arabidopsis thaliana Plants and Fungi PD-1 PD1 ncbigene_symbol PD1 817329
Arabidopsis thaliana Plants and Fungi SHP-1 SHP1 ncbigene_symbol SHP1 825047
Arabidopsis thaliana Plants and Fungi SHP-2 SHP2 ncbigene_symbol SHP2 818883
Arabidopsis thaliana Plants and Fungi AP1 AP1 ncbigene_symbol AP1 843244
Arabidopsis thaliana Plants and Fungi otc.) OTC ncbigene_symbol OTC 843869

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA