Adipocytokines and Hepatic Fibrosis

The profibrogenic role of leptin requires leptin-signaling via activation of the long form of leptin receptor (Ob-Rb) and the downstream Jak/Stat pathway. Conversely, adiponectin inhibits leptin signaling via activating protein tyrosine phosphate 1B (PTP1B) and suppressors of cytokine 3 (SOCS3), via the AdipoR2. Adiponectin opposes leptin signaling during the perpetuation stage of liver fibrosis by down regulating tissue inhibitor of metalloproteinase I (TIMP-1) expression and activity, along with concomitant increases in both transcriptional activation of matrix metalloproteinase 1 (MMP-1) and MMP-1 protease activity.
Adipocytokines and Hepatic Fibrosis
Download JPG
View figure at PMC Read paper at PMC Open at NDEx
PMC
NDEx

Publication

Adipocytokines and Hepatic Fibrosis. (2015) Neeraj K. Saxena, et al. Trends Endocrinol Metab. 2015 Mar;26(3):153-161. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates Jak2 JAK2 ncbigene_symbol JAK2 3717
Homo sapiens Primates PTP1B PTP1B ncbigene_synonym PTPN1 5770
Homo sapiens Primates APPL1 APPL1 ncbigene_symbol APPL1 26060
Homo sapiens Primates SHP-2 SHP2 ncbigene_synonym PTPN11 5781
Homo sapiens Primates SOCS3 SOCS3 ncbigene_symbol SOCS3 9021
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA1 5562
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA2 5563
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAB1 5564
Homo sapiens Primates AMPK AMPK famplex_relations PRKAB2 5565
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG1 5571
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG2 51422
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG3 53632
Homo sapiens Primates Stat3 STAT3 ncbigene_symbol STAT3 6774
Homo sapiens Primates HSC HSC ncbigene_synonym FUT1 2523
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL6A1 1291
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL6A2 1292
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL6A3 1293
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL6A5 256076
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL6A6 131873
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL7A1 1294
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL8A1 1295
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL8A2 1296
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL9A1 1297
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL9A2 1298
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL9A3 1299
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL10A1 1300
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL11A1 1301
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL11A2 1302
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL12A1 1303
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL13A1 1305
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL14A1 7373
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL15A1 1306
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL16A1 1307
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL17A1 1308
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL18A1 80781
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL19A1 1310
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL20A1 57642
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL21A1 81578
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL22A1 169044
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL23A1 91522
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL24A1 255631
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL25A1 84570
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL26A1 136227
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL27A1 85301
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL28A1 340267
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL1A1 1277
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL1A2 1278
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL4A1 1282
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL4A2 1284
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL4A3 1285
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL4A4 1286
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL4A5 1287
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL4A6 1288
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL5A1 1289
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL5A2 1290
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL5A3 50509
Homo sapiens Primates a1collagen,TIMP-1 TIMP-1 ncbigene_synonym TIMP1 7076
Homo sapiens Primates a1 A1 ncbigene_synonym ADRA1D 146

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID