Diagrammatic representation of mammalian target of rapamycin pathway: A crucial intersection of type 2 diabetes and Alzheimer’s disease

Diagrammatic representation of mammalian target of rapamycin pathway: A crucial intersection of type 2 diabetes and Alzheimer’s disease. Diabetes results in dysfunctional insulin signaling which brings mTOR pathway down and ultimately results in autophagy failure to accumulate Aβ, inhibit re-entry of post mitotic neurons in cell cycle, stimulate aberrant growth pathways, lose of translational control and impaired neurogenesis, etc. T2D: Type 2 diabetes; IGF: Insulin like growth factor; mTOR: Mammalian target of rapamycin; Aβ: Amyloid beta; ROS: Reactive oxygen species.
Diagrammatic representation of mammalian target of rapamycin pathway: A crucial intersection of type 2 diabetes and Alzheimer’s disease
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Publication

Molecular and biochemical trajectories from diabetes to Alzheimer’s disease: A critical appraisal. (2015) Rajat Sandhir, et al. World J Diabetes. 2015 Sep 25;6(12):1223-1242. Figure: F5.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates Shc SHC ncbigene_symbol Shc 44052
Drosophila melanogaster Invertebrates Low LOW ncbigene_symbol Low 44325
Drosophila melanogaster Invertebrates Grb2 GRB2 ncbigene_synonym drk 36497
Drosophila melanogaster Invertebrates sos SOS ncbigene_symbol Sos 34790
Drosophila melanogaster Invertebrates AMP/ATPhigh AMP ncbigene_synonym Amph 36383
Drosophila melanogaster Invertebrates ATP ATP ncbigene_synonym ATPsynbeta 43829
Drosophila melanogaster Invertebrates ATP ATP ncbigene_synonym Atpalpha 48971
Drosophila melanogaster Invertebrates (GluR1,PSD95) GLUR1 ncbigene_synonym GluRIA 38742
Drosophila melanogaster Invertebrates (GluR1,PSD95) PSD95 ncbigene_synonym dlg1 32083
Drosophila melanogaster Invertebrates Raf RAF ncbigene_symbol Raf 31221
Drosophila melanogaster Invertebrates Akt AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates AMPK AMPK ncbigene_synonym SNF4Agamma 42515
Drosophila melanogaster Invertebrates AMPK AMPK ncbigene_synonym AMPKalpha 43904
Drosophila melanogaster Invertebrates TSC TSC ncbigene_symbol Tsc 247509
Drosophila melanogaster Invertebrates TSC TSC ncbigene_synonym Tsc1 42862
Drosophila melanogaster Invertebrates Rheb RHEB ncbigene_symbol Rheb 117332
Drosophila melanogaster Invertebrates MEK MEK ncbigene_synonym Dsor1 31872
Drosophila melanogaster Invertebrates MEK MEK ncbigene_synonym Mtk 36708
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_synonym Tor 47396
Drosophila melanogaster Invertebrates ERK ERK ncbigene_synonym Erk7 31877
Drosophila melanogaster Invertebrates ERK ERK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates cycle CYCLE ncbigene_synonym CycE 34924
Drosophila melanogaster Invertebrates cycle CYCLE ncbigene_synonym cyc 40162
Drosophila melanogaster Invertebrates and AND ncbigene_synonym CkIIbeta 32132
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Andorra 32798
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Anp 43595
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Acam 44913
Drosophila melanogaster Invertebrates steps STEP ncbigene_symbol step 35425
Drosophila melanogaster Invertebrates Ap AP ncbigene_symbol ap 35509
Drosophila melanogaster Invertebrates AB AB ncbigene_symbol ab 34560
Drosophila melanogaster Invertebrates AB AB ncbigene_synonym Appl 31002
Homo sapiens Primates T2D T2D ncbigene_synonym NEUROD1 4760
Homo sapiens Primates T2D T2D ncbigene_synonym HNF1B 6928
Homo sapiens Primates Shc SHC ncbigene_synonym SHC1 6464
Homo sapiens Primates Shc SHC famplex_relations SHC2 25759
Homo sapiens Primates Shc SHC famplex_relations SHC3 53358
Homo sapiens Primates Shc SHC famplex_relations SHC4 399694
Homo sapiens Primates Grb2 GRB2 ncbigene_symbol GRB2 2885
Homo sapiens Primates sos SOS ncbigene_synonym XYLT2 64132
Homo sapiens Primates sos SOS famplex_relations SOS1 6654
Homo sapiens Primates sos SOS famplex_relations SOS2 6655
Homo sapiens Primates AMP/ATPhigh AMP ncbigene_synonym APRT 353
Homo sapiens Primates AMP/ATPhigh AMP ncbigene_synonym MFAP1 4236
Homo sapiens Primates ATP ATP ncbigene_synonym ATP8A2 51761
Homo sapiens Primates (GluR1,PSD95) GLUR1 ncbigene_synonym GRIA1 2890
Homo sapiens Primates (GluR1,PSD95) PSD95 ncbigene_synonym DLG4 1742
Homo sapiens Primates Raf RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates Raf RAF famplex_relations ARAF 369
Homo sapiens Primates Raf RAF famplex_relations BRAF 673
Homo sapiens Primates Raf RAF famplex_relations RAF1 5894
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA1 5562
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA2 5563
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAB1 5564
Homo sapiens Primates AMPK AMPK famplex_relations PRKAB2 5565
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG1 5571
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG2 51422
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG3 53632
Homo sapiens Primates TSC TSC ncbigene_synonym SLC12A3 6559
Homo sapiens Primates TSC TSC ncbigene_synonym TSC1 7248
Homo sapiens Primates TSC TSC ncbigene_synonym TESC 54997
Homo sapiens Primates TSC TSC famplex_relations TSC2 7249
Homo sapiens Primates Rheb RHEB ncbigene_symbol RHEB 6009
Homo sapiens Primates Rheb RHEB ncbigene_synonym RHEBP1 6008
Homo sapiens Primates MEK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates MEK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates MEK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates MTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates ERK ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates ERK ERK famplex_relations MAPK3 5595
Homo sapiens Primates steps STEP ncbigene_synonym PTPN5 84867
Homo sapiens Primates AB AB ncbigene_synonym APP 351
Homo sapiens Primates AB AB ncbigene_synonym SUCLA2 8803

Chemical mentions

Word Match MeSH Name ChEBI
Glucose Glucose mesh:D005947 D-glucopyranose chebi:4167
glucose Glucose mesh:D005947 D-glucopyranose chebi:4167

Disease mentions

Word Match MeSH Name DOID
Cancer NA
Cardiomyopathy NA
Noonan syndrome NA