BMI-1 is important in the regulation of cancer and CSCs, functioning through the activation of multiple signaling pathways
BMI-1 is important in the regulation of cancer and CSCs, functioning through the activation of multiple signaling pathways. BMI-1 expression is upregulated by MYC, SALL4, Nrf2 and is downregulated by Mel-18. BMI-1 regulates cancer cell invasion/metastasis and chemosensitivity by regulating VEGF, PTEN and PI3K/AKT signaling pathway. BMI-1 regulates CSC differentiation through repression of Hox genes, regulates self-renewal and malignant transformation through repression of Ink4a/Arf genes. CSC, cancer stem cell; VEGF, vascular endothelial growth factor. Nrf2, nuclear factor erythroid 2-related factor 2.
Publication
BMI-1, a promising therapeutic target for human cancer. (2015) MIN-CONG WANG, et al. Oncol Lett. 2015 Aug;10(2):583-588. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Danio rerio | Vertebrates | SALL4 | SALL4 | ncbigene_symbol | sall4 | 572527 |
| Danio rerio | Vertebrates | MYC | MYC | ncbigene_synonym | myca | 30686 |
| Danio rerio | Vertebrates | MYC | MYC | ncbigene_synonym | mycbp2 | 368439 |
| Danio rerio | Vertebrates | Nrf2 | NRF2 | ncbigene_synonym | nfe2l2a | 360149 |
| Danio rerio | Vertebrates | Mel-18 | ME1 | ncbigene_symbol | me1 | 768196 |
| Danio rerio | Vertebrates | Mel-18 | ME3 | ncbigene_symbol | me3 | 492719 |
| Danio rerio | Vertebrates | Mel-18 | ME2 | ncbigene_symbol | me2 | 445233 |
| Danio rerio | Vertebrates | BMI-1 | BMI1 | ncbigene_synonym | bmi1a | 321505 |
| Danio rerio | Vertebrates | VEGF | VEGF | ncbigene_synonym | vegfaa | 30682 |
| Homo sapiens | Primates | SALL4 | SALL4 | ncbigene_symbol | SALL4 | 57167 |
| Homo sapiens | Primates | MYC | MYC | ncbigene_symbol | MYC | 4609 |
| Homo sapiens | Primates | Nrf2 | NRF2 | ncbigene_synonym | GABPA | 2551 |
| Homo sapiens | Primates | Nrf2 | NRF2 | ncbigene_synonym | NFE2L2 | 4780 |
| Homo sapiens | Primates | Mel-18 | MEL-18 | ncbigene_synonym | PCGF2 | 7703 |
| Homo sapiens | Primates | BMI-1 | BMI1 | ncbigene_symbol | BMI1 | 648 |
| Homo sapiens | Primates | BMI-1 | BMI1 | ncbigene_synonym | COMMD3-BMI1 | 100532731 |
| Homo sapiens | Primates | Arf | ARF | ncbigene_synonym | CDKN2A | 1029 |
| Homo sapiens | Primates | AKT | AKT | ncbigene_synonym | AKT1 | 207 |
| Homo sapiens | Primates | AKT | AKT | famplex_relations | AKT2 | 208 |
| Homo sapiens | Primates | AKT | AKT | famplex_relations | AKT3 | 10000 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CA | 5290 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CB | 5291 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CD | 5293 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CG | 5294 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R3 | 8503 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R4 | 30849 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R5 | 23533 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R6 | 146850 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R1 | 5295 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R2 | 5296 |
| Homo sapiens | Primates | VEGF | VEGF | ncbigene_synonym | VEGFA | 7422 |
| Homo sapiens | Primates | VEGF | VEGF | famplex_relations | VEGFB | 7423 |
| Homo sapiens | Primates | VEGF | VEGF | famplex_relations | VEGFC | 7424 |
| Homo sapiens | Primates | VEGF | VEGF | famplex_relations | VEGFD | 2277 |
| Homo sapiens | Primates | VEGF | VEGF | famplex_relations | PGF | 5228 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|---|---|---|---|
| Cancer | NA |