Schematic diagram of GABA metabolism and the mTOR pathway

Schematic diagram of GABA metabolism and the mTOR pathway. L-His, L-histidine; mTOR, mechanistic target of rapamycin; VGB, vigabatrin; GAD, glutamic acid decarboxylase; GABA-T, GABA-transaminase; SSA, succinic semialdehyde; GHB, gamma-hydroxybutyrate; SSADH, succinic semialdehyde dehydrogenase (the site of the defect in patients with inherited γ-hydroxybutyric aciduria [box]). S6 kinase (S6K) is a mammalian kinase activated by mTOR signaling.
Schematic diagram of GABA metabolism and the mTOR pathway
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Publication

Torin 1 partially corrects vigabatrin-induced mitochondrial increase in mouse. (2015) Kara R Vogel, et al. Ann Clin Transl Neurol. 2015 Jun;2(6):699-706. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents OH OH ncbigene_symbol oh 18299
Mus musculus Rodents SSADH SSADH ncbigene_synonym Aldh5a1 214579
Mus musculus Rodents GAD GAD ncbigene_synonym Uchl1 22223
Mus musculus Rodents GABA-T GABAT ncbigene_synonym Abat 268860
Mus musculus Rodents SSA SSA ncbigene_synonym Ro60 20822
Mus musculus Rodents Torin TORIN ncbigene_synonym Prdx2 21672
Mus musculus Rodents MTOR MTOR ncbigene_symbol Mtor 56717
Homo sapiens Primates SSADH SSADH ncbigene_synonym ALDH5A1 7915
Homo sapiens Primates GAD GAD ncbigene_synonym GAD1 2571
Homo sapiens Primates GAD GAD famplex_relations GAD2 2572
Homo sapiens Primates GABA-T GABAT ncbigene_synonym ABAT 18
Homo sapiens Primates SSA SSA ncbigene_synonym CALR 811
Homo sapiens Primates SSA SSA ncbigene_synonym TRIM21 6737
Homo sapiens Primates MTOR MTOR ncbigene_symbol MTOR 2475
Drosophila melanogaster Invertebrates HN HN ncbigene_symbol Hn 38871
Drosophila melanogaster Invertebrates SSADH SSADH ncbigene_symbol Ssadh 43092
Drosophila melanogaster Invertebrates GAD GAD ncbigene_synonym Gad1 38484
Drosophila melanogaster Invertebrates GABA-T GABAT ncbigene_symbol Gabat 40188
Drosophila melanogaster Invertebrates GABA GABA ncbigene_synonym GABA-B-R1 34878
Drosophila melanogaster Invertebrates GABA GABA ncbigene_synonym Rdl 39054
Drosophila melanogaster Invertebrates SSA SSA ncbigene_synonym ss 41988
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_synonym Tor 47396

Chemical mentions

Word Match MeSH Name ChEBI
Homocarnosine NA mesh:C005038
GABA gamma-Aminobutyric Acid mesh:D005680 gamma-aminobutyric acid chebi:16865
OH Succinate Succinates mesh:D013386 succinate chebi:26806
Glutamate NA mesh:D018698

Disease mentions

Word Match MeSH Name DOID