Functions of Klotho

a, Klotho inhibits the IGF signaling pathway. The downstream factors FOXO1, -3a, and -4 mediate the function of Klotho. b, Klotho suppresses the Wnt signaling pathway. c, Klotho regulates Trpv5 calcium channels. d, Klotho regulates PTH synthesis. e, The Klotho-FGF23 complex regulates Pi absorption, mineral metabolism, and vitamin D3 expression and activity.
Functions of Klotho
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Publication

Molecular Basis of Klotho: From Gene to Function in Aging. (2015) Yuechi Xu, et al. Endocr Rev. 2015 Apr;36(2):174-193. Figure: F4.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates AKT AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates Na+,K+-ATPase NAKATPASE ncbigene_synonym Atpalpha 48971
Drosophila melanogaster Invertebrates Na+,K+-ATPase KATPASE ncbigene_synonym nrv1 33952
Drosophila melanogaster Invertebrates Na+,K+-ATPase KATPASE ncbigene_synonym nrv2 33953
Drosophila melanogaster Invertebrates Na+,K+-ATPase NA ncbigene_symbol na 45338
Drosophila melanogaster Invertebrates FOXO1 FOXO1 ncbigene_synonym foxo 41709
Drosophila melanogaster Invertebrates Vd VD ncbigene_symbol vd 250599
Drosophila melanogaster Invertebrates MnSOD MNSOD ncbigene_synonym Sod2 36878
Drosophila melanogaster Invertebrates KLT KLT ncbigene_synonym DIP1 43981
Drosophila melanogaster Invertebrates ÇAda ADA ncbigene_symbol Ada 41092
Drosophila melanogaster Invertebrates ÇAda ADA ncbigene_synonym AP-2alpha 33211
Drosophila melanogaster Invertebrates KL1 KL1 ncbigene_symbol kl-1 251557
Homo sapiens Primates IGFR IGFR ncbigene_synonym IGF1R 3480
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates Na+,K+-ATPase NAKATPASE famplex_relations ATP1A1 476
Homo sapiens Primates Na+,K+-ATPase NAKATPASE famplex_relations ATP1A2 477
Homo sapiens Primates Na+,K+-ATPase NAKATPASE famplex_relations ATP1A3 478
Homo sapiens Primates Na+,K+-ATPase NAKATPASE famplex_relations ATP1A4 480
Homo sapiens Primates Na+,K+-ATPase NAKATPASE famplex_relations ATP1B1 481
Homo sapiens Primates Na+,K+-ATPase NAKATPASE famplex_relations ATP1B2 482
Homo sapiens Primates Na+,K+-ATPase NAKATPASE famplex_relations ATP1B3 483
Homo sapiens Primates Na+,K+-ATPase NAKATPASE famplex_relations ATP1B4 23439
Homo sapiens Primates FOXO1 FOXO1 ncbigene_symbol FOXO1 2308
Homo sapiens Primates Cyp24 CYP24 ncbigene_synonym CYP24A1 1591
Homo sapiens Primates Cyp27b1- CYP27B1 ncbigene_symbol CYP27B1 1594
Homo sapiens Primates FOXO4 FOXO4 ncbigene_symbol FOXO4 4303
Homo sapiens Primates MnSOD MNSOD ncbigene_synonym SOD2 6648
Homo sapiens Primates ÇAda ADA ncbigene_symbol ADA 100
Homo sapiens Primates ÇAda ADA famplex_relations ADAD1 132612
Homo sapiens Primates ÇAda ADA famplex_relations ADAD2 161931
Homo sapiens Primates ÇAda ADA famplex_relations ADAR 103
Homo sapiens Primates ÇAda ADA famplex_relations ADARB1 104
Homo sapiens Primates ÇAda ADA famplex_relations ADARB2 105
Homo sapiens Primates ÇAda ADA famplex_relations ADAT1 23536
Homo sapiens Primates ÇAda ADA famplex_relations ADAT2 134637
Homo sapiens Primates ÇAda ADA famplex_relations ADAT3 113179
Homo sapiens Primates KL1 KL1 ncbigene_synonym KITLG 4254

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA