Functions of CDK4/Cyclin D and CDK5/p25

Functions of CDK4/Cyclin D and CDK5/p25. (A) Function and regulation of CDK4/cyclin D: The expression of cyclin D (orange) via mitogenic signals leads to its association with CDK4 (blue) and formation of the complex. The binding with Cip/Kip proteins (light purple) is required for complex assembly and its nuclear localization. The activity of CDK4/cyclin D activity is negatively regulated by interaction with the INK4 protein family (pink). Once activated, CDK4/cyclin D regulates the progression through G1 phase and the transition into S phase. CDK4/cyclin D phosphorylates the retinoblastoma protein (Rb) (dark purple) inducing the derepression of E2F transcription factors (green) which allows the transcription of genes which are required for G1/S transition; (B) Different functions of CDK5 in the nervous system and schematic representation of CDK5 regulation through cleavage of p35 to p25 at the cellular membrane; when CDK5/p35 binds p27 and E2F1 and DP1 in the nucleus, the cell cycle is inactivated. When p27 is degraded CDK5/p35 returns to the cytoplasm and the cell death pathway is inactivated.

Publication

Targeting Cyclin-Dependent Kinases in Human Cancers: From Small Molecules to Peptide Inhibitors. (2015) Marion Peyressatre, et al. Cancers (Basel). 2015 Mar;7(1):179-237. Figure: F2. All organisms Homo sapiens Drosophila melanogaster

Disease mentions