Biosynthesis of Isoprenoid building blocks

Biosynthesis of Isoprenoid building blocks. The three pathways leading to the synthesis of IPP and DMAPP – MEP/DOXP pathway, Mevalonate and the alternate mevalonate pathway (in red), which is prevalent in archaea are shown. Mevalonate and the alternate mevalonate pathways share four of their seven enzymatic steps. The enzyme acronyms are written in bold. DXS, 1-Deoxy-d-xylulose 5-phosphate synthase; DXR, 1-Deoxy-d-xylulose 5-phosphate reductase; CMS, 2-C-methyl-d-erythriol 4-phosphate cytidyltransferase; CMK, 4-diphosphocytidyl-2-C-methyl-d-erythritol kinase; MCS, 2-C-methyl-d-erythritol 2,4-cyclodiphosphate synthase; HDS, (E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate synthase; HDR, (E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate reductase; IDI, Isopentenyl diphosphate isomerase; AACT, acetoacetyl-CoA thiolase; HMGS, 3-hydroxy-3-methylglutaryl-CoA synthase; HMGR, 3-hydroxy-3-methylglutaryl-CoA reductase; MVK, mevalonate kinase; PMK, phosphomevalonate kinase; MDC, mevalonate-5-decarboxylase; IPK, isopentenyl phosphate kinase.

Publication

Biosynthesis of archaeal membrane ether lipids. (2014) Samta Jain, et al. Front Microbiol. 2014;5:641. Figure: F1. All organisms Homo sapiens Drosophila melanogaster Escherichia coli str. K-12 substr. MG1655

Disease mentions