Cloning and Characterization of a Norbelladine 4′-O-Methyltransferase Involved in the Biosynthesis of the Alzheimer’s Drug Galanthamine in Narcissus sp. aff. pseudonarcissus

3,4-Dihydroxybenzaldehyde derived from phenylalanine and tyramine derived from tyrosine are condensed to form norbelladine. Norbelladine is methylated by NpN4OMT to 4′-O-methylnorbelladine. 4′-O-Methylnorbelladine is oxidized to N-demethylnarwedine. N-demethylnarwedine is then reduced to N-demethylgalanthamine. In the last step, N-demethylgalanthamine is methylated to galanthamine.

Publication

Cloning and Characterization of a Norbelladine 4′-O-Methyltransferase Involved in the Biosynthesis of the Alzheimer’s Drug Galanthamine in Narcissus sp. aff. pseudonarcissus . (2014) Matthew B. Kilgore, et al. PLoS One. 2014;9(7):e103223. Figure: F1.

Disease mentions