The Kennedy pathway of phosphatidylcholine synthesis and breakdown to phosphatidic acid
The Kennedy pathway of phosphatidylcholine synthesis and breakdown to phosphatidic acid. PLA2/A1, phospholipase A2/A1; LPL, lysophospholipase. (; ).
Publication
Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo. (2014) T E Bapiro, et al. Br J Cancer. 2014 Jul 15;111(2):318-325. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Drosophila melanogaster | Invertebrates | CK | CK | ncbigene_symbol | ck | 34882 |
| Drosophila melanogaster | Invertebrates | CTP | CTP | ncbigene_symbol | ctp | 31405 |
| Drosophila melanogaster | Invertebrates | CPT | CPT | ncbigene_symbol | Cpt | 248169 |
| Drosophila melanogaster | Invertebrates | CPT | CPT | ncbigene_synonym | CG7149 | 34063 |
| Drosophila melanogaster | Invertebrates | CPT | CPT | ncbigene_synonym | CPT2 | 38355 |
| Drosophila melanogaster | Invertebrates | CMP | CMP | ncbigene_symbol | cmp | 248126 |
| Homo sapiens | Primates | CTP | CTP | ncbigene_synonym | SLC25A1 | 6576 |
| Homo sapiens | Primates | CDP | CDP | ncbigene_synonym | CUX1 | 1523 |
| Homo sapiens | Primates | CDP | CDP | ncbigene_synonym | NPPA | 4878 |
| Homo sapiens | Primates | CPT | CPT | ncbigene_synonym | CHPT1 | 56994 |
| Homo sapiens | Primates | CPT | CPT | ncbigene_synonym | DHDDS | 79947 |
| Homo sapiens | Primates | CMP | CMP | ncbigene_synonym | MATN1 | 4146 |
| Homo sapiens | Primates | LPL | LPL | ncbigene_symbol | LPL | 4023 |
| Homo sapiens | Primates | LPL | LPL | ncbigene_synonym | LCP1 | 3936 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Choline | Choline | mesh:D002794 | choline | chebi:15354 |
| CDP choline | Cytidine Diphosphate Choline | mesh:D003566 | CDP-choline | chebi:16436 |
| CMP | Cytidine Monophosphate | mesh:D003568 | cytidine 5'-monophosphate | chebi:17361 |
| Docosahexaenoate | Docosahexaenoic Acids | mesh:D004281 | docosahexaenoic acid | chebi:36005 |
| Lysophosphatidylcholine | Lysophosphatidylcholines | mesh:D008244 | lysophosphatidylcholine | chebi:60479 |
| Phosphatidic acid | Phosphatidic Acids | mesh:D010712 | phosphatidic acid | chebi:16337 |
| Phosphatidylcholine | Phosphatidylcholines | mesh:D010713 | phosphatidylcholine(1+) | chebi:49183 |
| Phosphocholine | Phosphorylcholine | mesh:D010767 | phosphocholine | chebi:18132 |
| Linoleate | linoleic acid | mesh:D019787 | Linoleic Acid | chebi:17351 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|