PI3K/AKT/GSK-3B signaling pathway in neuronal cells of Alzheimer’s disease

Schematic representation of PI3K/AKT/GSK-3β signaling pathway in neuronal cells of Alzheimer’s disease. Examples of molecules known to act on the regulatory pathways are shown. Note that some critical pathways have been omitted for clarity. 5-HT, 5-hydroxytryptamine, serotonin; BDNF, brain-derived neurotrophic factor; CDK5, cyclin-dependent kinase 5; GSK-3β, glycogen synthase kinase-3β; IKK, IκB kinase; NF-κB, nuclear factor-kappa-B; p38-MAPK, p38 mitogen-activated protein kinase; PI3K, phosphoinositide-3 kinase; PP2A, protein phosphatase 2A; TrkB, tropomyosin-receptor-kinase B; TSP1, thrombospondin-1.
PI3K/AKT/GSK-3B signaling pathway in neuronal cells of Alzheimer’s disease
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Publication

Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease. (2014) Yasuko Kitagishi, et al. Alzheimers Res Ther. 2014;6(3):35-35. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents BDNF BDNF ncbigene_symbol Bdnf 12064
Mus musculus Rodents TrkB TRKB ncbigene_synonym Ntrk2 18212
Mus musculus Rodents PI3K PI3K ncbigene_synonym Pik3r1 18708
Mus musculus Rodents AKT AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents PP2A PP2A ncbigene_synonym Ppp2ca 19052
Mus musculus Rodents PP2A PP2A ncbigene_synonym Ppp2r1a 51792
Mus musculus Rodents GSK-3B GSK-3B ncbigene_synonym Gsk3b 56637
Mus musculus Rodents TSP1 TSP1 ncbigene_symbol Tsp1 108314
Mus musculus Rodents TSP1 TSP1 ncbigene_synonym Gzma 14938
Mus musculus Rodents TSP1 TSP1 ncbigene_synonym Thbs1 21825
Mus musculus Rodents p38-MAPK P38MAPK ncbigene_synonym Mapk14 26416
Mus musculus Rodents Caspase3/9 CASPASE9 ncbigene_synonym Casp9 12371
Mus musculus Rodents Caspase3/9 CASPASE3 ncbigene_synonym Casp3 12367
Mus musculus Rodents NF-KB NF-KB ncbigene_synonym Nfkb1 18033
Mus musculus Rodents CDK5 CDK5 ncbigene_symbol Cdk5 12568
Mus musculus Rodents Tau TAU ncbigene_synonym Mapt 17762
Mus musculus Rodents Tau TAU ncbigene_synonym Csnk1e 27373
Homo sapiens Primates BDNF BDNF ncbigene_symbol BDNF 627
Homo sapiens Primates BDNF BDNF ncbigene_synonym BDNF-AS 497258
Homo sapiens Primates TrkB TRKB ncbigene_synonym NTRK2 4915
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates PP2A PP2A ncbigene_synonym PTPA 5524
Homo sapiens Primates GSK-3B GSK3B ncbigene_symbol GSK3B 2932
Homo sapiens Primates TSP1 TSP1 ncbigene_synonym THBS1 7057
Homo sapiens Primates TSP1 TSP1 ncbigene_synonym CRISP2 7180
Homo sapiens Primates TSP1 TSP1 ncbigene_synonym PRSS55 203074
Homo sapiens Primates IKK IKK famplex_relations CHUK 1147
Homo sapiens Primates IKK IKK famplex_relations IKBKB 3551
Homo sapiens Primates IKK IKK famplex_relations IKBKG 8517
Homo sapiens Primates IKK IKK famplex_relations IKBKE 9641
Homo sapiens Primates IKK IKK famplex_relations TBK1 29110
Homo sapiens Primates Caspase CASPASE famplex_relations CASP1 834
Homo sapiens Primates Caspase CASPASE famplex_relations CASP2 835
Homo sapiens Primates Caspase CASPASE famplex_relations CASP4 837
Homo sapiens Primates Caspase CASPASE famplex_relations CASP5 838
Homo sapiens Primates Caspase CASPASE famplex_relations CASP6 839
Homo sapiens Primates Caspase CASPASE famplex_relations CASP8 841
Homo sapiens Primates Caspase CASPASE famplex_relations CASP9 842
Homo sapiens Primates Caspase CASPASE famplex_relations CASP10 843
Homo sapiens Primates Caspase CASPASE famplex_relations CASP12 100506742
Homo sapiens Primates Caspase CASPASE famplex_relations CASP14 23581
Homo sapiens Primates Caspase CASPASE famplex_relations CASP3 836
Homo sapiens Primates Caspase CASPASE famplex_relations CASP7 840
Homo sapiens Primates NF-KB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates CDK5 CDK5 ncbigene_symbol CDK5 1020
Homo sapiens Primates Tau TAU ncbigene_synonym MAPT 4137
Rattus norvegicus Rodents BDNF BDNF ncbigene_symbol Bdnf 24225
Rattus norvegicus Rodents TrkB TRKB ncbigene_synonym Ntrk2 25054
Rattus norvegicus Rodents PI3K PI3K ncbigene_synonym Pik3cg 298947
Rattus norvegicus Rodents AKT AKT ncbigene_synonym Akt1 24185
Rattus norvegicus Rodents GSK-3B GSK3B ncbigene_symbol Gsk3b 84027
Rattus norvegicus Rodents TSP1 TSP1 ncbigene_synonym Thbs1 445442
Rattus norvegicus Rodents NF-KB NF-KB ncbigene_synonym Nfkb1 81736
Rattus norvegicus Rodents CDK5 CDK5 ncbigene_symbol Cdk5 140908
Rattus norvegicus Rodents Tau TAU ncbigene_synonym Mapt 29477
Drosophila melanogaster Invertebrates 5HT 5HT ncbigene_synonym 5-HT1B 37191
Drosophila melanogaster Invertebrates 5HT 5HT ncbigene_synonym 5-HT1A 37196
Drosophila melanogaster Invertebrates 5HT 5HT ncbigene_synonym 5-HT2A 40575
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates AKT AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates PP2A PP2A ncbigene_synonym wrd 42169
Drosophila melanogaster Invertebrates PP2A PP2A ncbigene_synonym wdb 43312
Drosophila melanogaster Invertebrates PP2A PP2A ncbigene_synonym mts 45959
Drosophila melanogaster Invertebrates PP2A PP2A ncbigene_synonym tws 47877
Drosophila melanogaster Invertebrates PP2A PP2A ncbigene_synonym Pp2A-29B 2768940
Drosophila melanogaster Invertebrates GSK-3B GSK-3B ncbigene_synonym sgg 31248
Drosophila melanogaster Invertebrates GSK-3B GSK-3B ncbigene_synonym gskt 318552
Drosophila melanogaster Invertebrates IKK IKK ncbigene_synonym IKKepsilon 35329
Drosophila melanogaster Invertebrates IKK IKK ncbigene_synonym key 37967
Drosophila melanogaster Invertebrates IKK IKK ncbigene_synonym IKKbeta 44432
Drosophila melanogaster Invertebrates p38-MAPK P38MAPK ncbigene_synonym p38b 34780
Drosophila melanogaster Invertebrates p38-MAPK P38MAPK ncbigene_synonym p38a 42866
Drosophila melanogaster Invertebrates p38-MAPK P38MAPK ncbigene_synonym p38c 2768679
Drosophila melanogaster Invertebrates Caspase3/9 CASPASE9 ncbigene_synonym Dronc 39173
Drosophila melanogaster Invertebrates Caspase3/9 CASPASE3 ncbigene_synonym Decay 42008
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym Dif 35045
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym dl 35047
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym Rel 41087
Drosophila melanogaster Invertebrates CDK5 CDK5 ncbigene_symbol Cdk5 36727
Drosophila melanogaster Invertebrates Tau TAU ncbigene_symbol tau 326116

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID