The ERK1/2 MAPK signaling network controlled by receptor tyrosine kinases and Ras

Model of the ERK1/2 MAPK signaling network controlled by receptor tyrosine kinases and Ras. ERK1/2 is part of a three kinase cascade involving BRaf/Raf1 and MEK1/2. MAP3K1 (also known as MEKK1) and Tpl2/COT (also known as MAP3K8) function as MAP3Ks that can also phosphorylate and activate MEK1/2 and regulate and bypass Raf inhibition. ERK1/2 phosphorylate upstream kinases including BRaf/Raf1 and MEK1 to feedback inhibit their activity. ERK1/2 also phosphorylates and inhibits the Ras guanine nucleotide exchange activity of SOS.
The ERK1/2 MAPK signaling network controlled by receptor tyrosine kinases and Ras
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Publication

Molecular Pathways: Adaptive Kinome Reprogramming in Response to Targeted Inhibition of the BRAF-MEK-ERK Pathway in Cancer. () Gary L. Johnson, et al. Clin Cancer Res. ;20(10):2516-2522. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents GRB2 GRB2 ncbigene_symbol Grb2 14784
Mus musculus Rodents Ras RAS ncbigene_symbol ras 19412
Mus musculus Rodents Ras RAS ncbigene_synonym Hras 15461
Mus musculus Rodents Ras RAS ncbigene_synonym Kras 16653
Mus musculus Rodents Ras RAS ncbigene_synonym Rem1 19700
Mus musculus Rodents Raf1 RAF1 ncbigene_symbol Raf1 110157
Mus musculus Rodents Raf1 RAF1 ncbigene_synonym Ear1 13586
Mus musculus Rodents Raf RAF ncbigene_synonym Zhx2 387609
Mus musculus Rodents BRaf BRAF ncbigene_symbol Braf 109880
Mus musculus Rodents BRaf BRAF ncbigene_synonym Braf-rs1 110709
Mus musculus Rodents MAP3K1 MAP3K1 ncbigene_symbol Map3k1 26401
Mus musculus Rodents Tpl2 TPL2 ncbigene_synonym Map3k8 26410
Mus musculus Rodents Tpl2 TPI2 ncbigene_synonym Tpi-rs2 111205
Mus musculus Rodents MEK1 MEK1 ncbigene_synonym Map2k1 26395
Mus musculus Rodents MEK1/2 MEK2 ncbigene_synonym Map2k2 26396
Mus musculus Rodents ERK1 ERK1 ncbigene_synonym Mapk3 26417
Mus musculus Rodents ERK1/2 ERK2 ncbigene_synonym Mapk1 26413
Mus musculus Rodents Rsk,Msk,Mnk MNK ncbigene_synonym Atp7a 11977
Mus musculus Rodents Rsk,Msk,Mnk RSK ncbigene_synonym Rps6ka1 20111
Mus musculus Rodents Rsk,Msk,Mnk MSK ncbigene_synonym Sik1 17691
Mus musculus Rodents HDAC6 HDAC6 ncbigene_symbol Hdac6 15185
Mus musculus Rodents cMyc,Ets,Fos FOS ncbigene_symbol Fos 14281
Mus musculus Rodents Elk, ELK ncbigene_synonym Kcnh8 211468
Mus musculus Rodents Elk, ELK ncbigene_synonym Ephb1 270190
Mus musculus Rodents Elk,JunB JUNB ncbigene_symbol Junb 16477
Mus musculus Rodents PI4K2 PI4K2 ncbigene_synonym Pi4k2a 84095
Mus musculus Rodents cPla2 CPLA2 ncbigene_synonym Pla2g4a 18783
Mus musculus Rodents cPla2 CPLA2 ncbigene_synonym Kat5 81601
Mus musculus Rodents Bad BAD ncbigene_symbol Bad 12015
Homo sapiens Primates GRB2 GRB2 ncbigene_symbol GRB2 2885
Homo sapiens Primates SPRY SPRY famplex_relations SPRY1 10252
Homo sapiens Primates SPRY SPRY famplex_relations SPRY2 10253
Homo sapiens Primates SPRY SPRY famplex_relations SPRY3 10251
Homo sapiens Primates SPRY SPRY famplex_relations SPRY4 81848
Homo sapiens Primates SOS SOS ncbigene_synonym XYLT2 64132
Homo sapiens Primates SOS SOS famplex_relations SOS1 6654
Homo sapiens Primates SOS SOS famplex_relations SOS2 6655
Homo sapiens Primates Ras RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras RAS famplex_relations NRAS 4893
Homo sapiens Primates Raf1 RAF1 ncbigene_symbol RAF1 5894
Homo sapiens Primates Raf1 RAF1 ncbigene_synonym RNASE3 6037
Homo sapiens Primates Raf RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates Raf RAF famplex_relations ARAF 369
Homo sapiens Primates Raf RAF famplex_relations BRAF 673
Homo sapiens Primates MAP3K1 MAP3K1 ncbigene_symbol MAP3K1 4214
Homo sapiens Primates Tpl2 TPL2 ncbigene_synonym MAP3K8 1326
Homo sapiens Primates COT COT ncbigene_synonym CROT 54677
Homo sapiens Primates MEK1 MEK1 ncbigene_synonym MAP2K1 5604
Homo sapiens Primates MEK1/2 MEK2 ncbigene_synonym MAP2K2 5605
Homo sapiens Primates ERK1 ERK1 ncbigene_synonym MAPK3 5595
Homo sapiens Primates ERK1/2 ERK2 ncbigene_synonym MAPK1 5594
Homo sapiens Primates Rsk,Msk,Mnk MNK ncbigene_synonym ATP7A 538
Homo sapiens Primates Rsk,Msk,Mnk RSK ncbigene_synonym RPS6KA1 6195
Homo sapiens Primates Rsk,Msk,Mnk RSK ncbigene_synonym RPS6KA2 6196
Homo sapiens Primates Rsk,Msk,Mnk RSK ncbigene_synonym RPS6KA3 6197
Homo sapiens Primates Rsk,Msk,Mnk RSK famplex_relations RPS6KA4 8986
Homo sapiens Primates Rsk,Msk,Mnk RSK famplex_relations RPS6KA5 9252
Homo sapiens Primates Rsk,Msk,Mnk RSK famplex_relations RPS6KA6 27330
Homo sapiens Primates Rsk,Msk,Mnk RSK famplex_relations RPS6KB1 6198
Homo sapiens Primates Rsk,Msk,Mnk RSK famplex_relations RPS6KB2 6199
Homo sapiens Primates Rsk,Msk,Mnk MSK ncbigene_synonym SIK1 150094
Homo sapiens Primates HDAC6 HDAC6 ncbigene_symbol HDAC6 10013
Homo sapiens Primates cMyc, CMYC ncbigene_synonym MYC 4609
Homo sapiens Primates cMyc,Ets,Fos ETS famplex_relations ETS1 2113
Homo sapiens Primates cMyc,Ets,Fos ETS famplex_relations ETS2 2114
Homo sapiens Primates cMyc,Ets,Fos FOS ncbigene_symbol FOS 2353
Homo sapiens Primates cMyc,Ets,Fos FOS famplex_relations FOSB 2354
Homo sapiens Primates cMyc,Ets,Fos FOS famplex_relations FOSL1 8061
Homo sapiens Primates cMyc,Ets,Fos FOS famplex_relations FOSL2 2355
Homo sapiens Primates Elk, ELK ncbigene_synonym EPHB1 2047
Homo sapiens Primates Elk, ELK ncbigene_synonym KCNH8 131096
Homo sapiens Primates Elk, E1K ncbigene_synonym OGDH 4967
Homo sapiens Primates Elk,JunB JUNB ncbigene_symbol JUNB 3726
Homo sapiens Primates Elk,JunB JUNB ncbigene_synonym RNASEH2A 10535
Homo sapiens Primates EIF4EBP EIF4EBP famplex_relations EIF4EBP1 1978
Homo sapiens Primates EIF4EBP EIF4EBP famplex_relations EIF4EBP2 1979
Homo sapiens Primates EIF4EBP EIF4EBP famplex_relations EIF4EBP3 8637
Homo sapiens Primates cPla2 CPLA2 ncbigene_synonym PLA2G4A 5321
Homo sapiens Primates cPla2 CPLA2 ncbigene_synonym KAT5 10524
Homo sapiens Primates Bad BAD ncbigene_symbol BAD 572
Drosophila melanogaster Invertebrates GRB2 GRB2 ncbigene_synonym drk 36497
Drosophila melanogaster Invertebrates SPRY SPRY ncbigene_synonym sty 38424
Drosophila melanogaster Invertebrates SOS SOS ncbigene_symbol Sos 34790
Drosophila melanogaster Invertebrates Ras RAS ncbigene_symbol ras 43873
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras64B 38494
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras85D 41140
Drosophila melanogaster Invertebrates Raf1 RAF1 ncbigene_synonym Raf 31221
Drosophila melanogaster Invertebrates COT COT ncbigene_synonym mir-ban 12798547
Drosophila melanogaster Invertebrates MEK1/2 MEK1/2 ncbigene_synonym Dsor1 31872
Drosophila melanogaster Invertebrates ERK1 ERK1 ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates Rsk,Msk,Mnk MNK ncbigene_synonym lok 35288
Drosophila melanogaster Invertebrates Rsk,Msk,Mnk RSK ncbigene_synonym S6kII 33139
Drosophila melanogaster Invertebrates Rsk,Msk,Mnk MSK ncbigene_symbol msk 44747
Drosophila melanogaster Invertebrates Rsk,Msk,Mnk MSK ncbigene_synonym JIL-1 39241
Drosophila melanogaster Invertebrates HDAC6 HDAC6 ncbigene_symbol HDAC6 32461
Drosophila melanogaster Invertebrates cMyc, CMYC ncbigene_synonym Myc 31310
Drosophila melanogaster Invertebrates cMyc,Ets,Fos ETS ncbigene_synonym Ets21C 33229
Drosophila melanogaster Invertebrates cMyc,Ets,Fos ETS ncbigene_synonym Ets65A 38700
Drosophila melanogaster Invertebrates cMyc,Ets,Fos ETS ncbigene_synonym pnt 42757
Drosophila melanogaster Invertebrates cMyc,Ets,Fos ETS ncbigene_synonym Ets96B 42952
Drosophila melanogaster Invertebrates cMyc,Ets,Fos ETS ncbigene_synonym Ets97D 43236
Drosophila melanogaster Invertebrates cMyc,Ets,Fos ETS ncbigene_synonym Ets98B 43334
Drosophila melanogaster Invertebrates cMyc,Ets,Fos FOS ncbigene_synonym kay 3772082
Drosophila melanogaster Invertebrates Elk, ELK ncbigene_symbol Elk 37047
Drosophila melanogaster Invertebrates EIF4EBP EIF4EBP ncbigene_synonym Thor 33569
Drosophila melanogaster Invertebrates Bad BAD ncbigene_synonym cass 35053

Chemical mentions

Word Match MeSH Name ChEBI
Tyrosine Tyrosine mesh:D014443 L-tyrosine chebi:17895

Disease mentions

Word Match MeSH Name DOID
Cancer NA
Cardiomyopathy NA
Lung cancer NA
Noonan syndrome NA