Conceptual flow diagram (based on the data presented herein) depicting mechanistic link between p38 MAPK and IL-R signaling pathway activated by oxalate in HK-2 cells

Conceptual flow diagram (based on the data presented herein) depicting mechanistic link between p38 MAPK and IL-R signaling pathway activated by oxalate in HK-2 cells. Increased luminal oxalate levels may either lead to increased intracellular oxalate levels or may trigger p38 MAPK activation by acting on cell membranes; however, exact mechanisms have not been established. In any case, activated p38 MAPK may result in phosphorylation and activation of transcription factors that drive transcriptional activation of IL-2Rβ and consequent increase in IL-2Rβ protein levels.

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Oxalate upregulates expression of IL-2Rβ and activates IL-2R signaling in HK-2 cells, a line of human renal epithelial cells. (2014) Sweaty Koul, et al. Am J Physiol Renal Physiol. 2014 May 1;306(9):F1039-F1046. Figure: F7. Homo sapiens

Disease mentions