Signal pathways involved in renal IRI

Schematic diagram of signal pathways involved in renal IRI. Renal IRI induces oxidative stress and tissue injury, resulting in mitochondrial dysfunction and activation of the TLR2/4 signaling pathway, all of which are targets of baicalin treatment.
Signal pathways involved in renal IRI
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Publication

The protective effect of baicalin against renal ischemia-reperfusion injury through inhibition of inflammation and apoptosis. (2014) Miao Lin, et al. BMC Complement Altern Med. 2014;14:19-19. Figure: F4.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Rattus norvegicus Rodents MYD88 MYD88 ncbigene_symbol Myd88 301059
Rattus norvegicus Rodents NF-KB NF-KB ncbigene_synonym Nfkb1 81736
Rattus norvegicus Rodents Bax BAX ncbigene_symbol Bax 24887
Rattus norvegicus Rodents Bcl-2 BCL-2 ncbigene_synonym Bcl2 24224
Rattus norvegicus Rodents IL-6 IL6 ncbigene_symbol Il6 24498
Rattus norvegicus Rodents IL-1B IL1B ncbigene_symbol Il1b 24494
Rattus norvegicus Rodents TNF-a TNF-A ncbigene_synonym Tnf 24835
Rattus norvegicus Rodents TLR2/4 TLR2 ncbigene_symbol Tlr2 310553
Rattus norvegicus Rodents TLR2/4 TLR4 ncbigene_symbol Tlr4 29260
Homo sapiens Primates MYD88 MYD88 ncbigene_symbol MYD88 4615
Homo sapiens Primates NF-KB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates Bax BAX ncbigene_symbol BAX 581
Homo sapiens Primates Bcl-2 BCL-2 ncbigene_synonym BCL2 596
Homo sapiens Primates IL-6 IL-6 ncbigene_synonym IL6 3569
Homo sapiens Primates IL-1B IL1B ncbigene_symbol IL1B 3553
Homo sapiens Primates TNF-a TNF-A ncbigene_synonym TNF 7124
Homo sapiens Primates TLR2/4 TLR2 ncbigene_symbol TLR2 7097
Homo sapiens Primates TLR2/4 TLR4 ncbigene_symbol TLR4 7099
Homo sapiens Primates TLR TLR famplex_relations TLR1 7096
Homo sapiens Primates TLR TLR famplex_relations TLR3 7098
Homo sapiens Primates TLR TLR famplex_relations TLR5 7100
Homo sapiens Primates TLR TLR famplex_relations TLR6 10333
Homo sapiens Primates TLR TLR famplex_relations TLR7 51284
Homo sapiens Primates TLR TLR famplex_relations TLR8 51311
Homo sapiens Primates TLR TLR famplex_relations TLR9 54106
Homo sapiens Primates TLR TLR famplex_relations TLR10 81793
Mus musculus Rodents MYD88 MYD88 ncbigene_symbol Myd88 17874
Mus musculus Rodents IKB IKB ncbigene_synonym Nfkbib 18036
Mus musculus Rodents NF-KB NF-KB ncbigene_synonym Nfkb1 18033
Mus musculus Rodents Bax BAX ncbigene_symbol Bax 12028
Mus musculus Rodents Bax BAX ncbigene_synonym Nkx3-1 18095
Mus musculus Rodents Bcl-2 BCL-2 ncbigene_synonym Bcl2 12043
Mus musculus Rodents Caspase-9 CASPASE-9 ncbigene_synonym Casp9 12371
Mus musculus Rodents Caspase-3 CASPASE-3 ncbigene_synonym Casp3 12367
Mus musculus Rodents IL-6 IL-6 ncbigene_synonym Il6 16193
Mus musculus Rodents IL-1B IL-1B ncbigene_synonym Il1b 16176
Mus musculus Rodents TNF-a TNF-A ncbigene_synonym Tnf 21926
Mus musculus Rodents TLR2/4 TLR2 ncbigene_symbol Tlr2 24088
Mus musculus Rodents TLR2/4 TLR4 ncbigene_symbol Tlr4 21898
Danio rerio Vertebrates MYD88 MYD88 ncbigene_symbol myd88 403145
Danio rerio Vertebrates Bax BAX ncbigene_synonym baxa 58081
Danio rerio Vertebrates Bcl-2 BC2 ncbigene_synonym chmp2a 798901
Danio rerio Vertebrates IL-6 IL6 ncbigene_symbol il6 100885851
Danio rerio Vertebrates IL-1B IL1B ncbigene_symbol il1b 405770
Danio rerio Vertebrates TNF-a TNF-A ncbigene_synonym tnfb 554167
Danio rerio Vertebrates TLR2/4 TLR2 ncbigene_symbol tlr2 403125

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID