The muscarinic acetylcholine receptor subtypes M1–M5

Schematic illustration of the muscarinic acetylcholine receptor subtypes M1–M5. The seven transmembrane domains of the family A G-protein-coupled receptors (GPCRs) are highlighted in blue. The orthosteric binding site is indicated in red. A putative allosteric site is illustrated in green and not indicative of a singular or unique site. The downstream effectors indicate M1signaling related to the (a) amyloidogenic precursor protein (APP) and subsequent secretase activity to generate soluble amyloidogenic precursor protein alpha (sAPPα), soluble amyloidogenic precursor protein beta (sAPPβ) and Aβ. (b) NMDAR through the CAKβ and SFK pathway. Abbreviations: AC, adenylyl cyclase; ATP, adenosine triphosphate; cAMP, cyclic adenosine monophosphate; ERK1/2, extracellular signal-regulated kinase; IP3, inositol triphosphate; PKC, protein kinase C; PLC, phospholipase C, CAKβ, cell adhesion kinase β; SFK, Src family kinases.

Publication

Allosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer′s disease. () Bruce J. Melancon, et al. Drug Discov Today. ;18(0):10.1016/j.drudis.2013.09.005. Figure: F2. All organisms Mus musculus Homo sapiens Drosophila melanogaster

Disease mentions