Arginine, ornithine, and polyamine synthesis pathway

Arginine, ornithine, and polyamine synthesis pathway. Enzymes surrounded by a thick gray box were shown to be horizontally transferred from Bacteria (see main text). Metabolites – I: glutamate; II: N-acetylglutamate; III: N-acetylglutamyl-phosphate; IV: N-acetyl-glutamate semialdehyde; V: N-acetylornithine; VI: ornithine; VII: carbamoyl-phosphate; VIII: citruline; IX: aspartate; X: arginino succinate; XI: arginine; XII: fumarate; XIII: urea; XIV: agmatine; XV: putrescine; XVI: S-adenosylmethionine; XVII: S-adenosylmethioninamine; XVIII: spermidine; XIX: spermine. Enzymes – 2.1.3.3: ornithine carbamoyltransferase; 6.3.4.5: argininosuccinate synthase; 4.3.2.1: argininosuccinate lyase; 3.5.3.1: arginase; 4.1.1.17: ornithine decarboxylase; 3.5.1.14: aminoacylase; 3.5.1.16: acetylornithine deacetylase; 2.3.1.35: glutamate N-acetyltransferase; 2.6.1.11: acetylornithine aminotransferase; 1.2.1.38: N-acetyl-gamma-glutamyl-phosphate reductase; 2.7.2.8: acetylglutamate kinase; 2.3.1.1: amino-acid N-acetyltransferase; 3.5.3.11: agmatinase; 4.1.1.19: arginine decarboxylase; 4.1.1.50: adenosylmethionine decarboxylase; 2.5.1.16: spermidine synthase. Abbreviations as for Figure .

Publication

Endosymbiosis in trypanosomatids: the genomic cooperation between bacterium and host in the synthesis of essential amino acids is heavily influenced by multiple horizontal gene transfers. (2013) João MP Alves, et al. BMC Evol Biol. 2013;13:190-190. Figure: F7. Drosophila melanogaster

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