The p53-mediated apoptotic signaling pathways

Diagram shows a map of the regulators and molecular components of this pathway. The proteins are color coded according to their intrinsic disorder content evaluated by PONDR-FIT, with highly ordered ([IDP score]<10%), moderately disordered (10%≤ [IDP score]<30%), and highly disordered ([IDP score]≥30%) being shown as blue, pink, and red boxes, respectively. This diagram is based on the maps of the p53-mediated apoptotic signaling pathways available at ( http://www.ebioscience.com/resources/pathways/p53-mediated-apoptosis-pathway.htm) and ( http://www.qiagen.com/Products/Genes and Pathways/Pathway Details/?pwid=338) and on related information , , , and many other papers.
The p53-mediated apoptotic signaling pathways
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Publication

On the intrinsic disorder status of the major players in programmed cell death pathways. (2013) Alexey V Uversky, et al. F1000Res. 2013;2:190. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents TRAIL TRAIL ncbigene_synonym Tnfsf10 22035
Mus musculus Rodents DRS DRS ncbigene_synonym Srpx 51795
Mus musculus Rodents PERP PERP ncbigene_symbol Perp 64058
Mus musculus Rodents Fas FAS ncbigene_symbol Fas 14102
Mus musculus Rodents Fas FAS ncbigene_synonym Fasn 14104
Mus musculus Rodents Akt AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents NOM NOM ncbigene_synonym Cfh 12628
Mus musculus Rodents ATR ATR ncbigene_symbol Atr 245000
Mus musculus Rodents ATR ATR ncbigene_synonym Mmab 77697
Mus musculus Rodents ATM ATM ncbigene_symbol Atm 11920
Mus musculus Rodents ATM ATM ncbigene_synonym Tpm1 22003
Mus musculus Rodents Chk2 CHK2 ncbigene_synonym Chek2 50883
Mus musculus Rodents p53 P53 ncbigene_synonym Trp53 22059
Mus musculus Rodents PUMA PUMA ncbigene_synonym Bbc3 170770
Mus musculus Rodents SCL2 SCL2 ncbigene_symbol Scl2 110660
Mus musculus Rodents BAX BAX ncbigene_symbol Bax 12028
Mus musculus Rodents BAX BAX ncbigene_synonym Nkx3-1 18095
Mus musculus Rodents APAF1 APAF1 ncbigene_symbol Apaf1 11783
Homo sapiens Primates TRAIL TRAIL ncbigene_synonym TNFSF10 8743
Homo sapiens Primates DRS DRS ncbigene_synonym PNN 5411
Homo sapiens Primates DRS DRS ncbigene_synonym SRPX 8406
Homo sapiens Primates PERP PERP ncbigene_symbol PERP 64065
Homo sapiens Primates Fas FAS ncbigene_symbol FAS 355
Homo sapiens Primates Fas FAS ncbigene_synonym FASN 2194
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates Caspase CASPASE famplex_relations CASP1 834
Homo sapiens Primates Caspase CASPASE famplex_relations CASP2 835
Homo sapiens Primates Caspase CASPASE famplex_relations CASP4 837
Homo sapiens Primates Caspase CASPASE famplex_relations CASP5 838
Homo sapiens Primates Caspase CASPASE famplex_relations CASP6 839
Homo sapiens Primates Caspase CASPASE famplex_relations CASP8 841
Homo sapiens Primates Caspase CASPASE famplex_relations CASP9 842
Homo sapiens Primates Caspase CASPASE famplex_relations CASP10 843
Homo sapiens Primates Caspase CASPASE famplex_relations CASP12 100506742
Homo sapiens Primates Caspase CASPASE famplex_relations CASP14 23581
Homo sapiens Primates Caspase CASPASE famplex_relations CASP3 836
Homo sapiens Primates Caspase CASPASE famplex_relations CASP7 840
Homo sapiens Primates ATR ATR ncbigene_symbol ATR 545
Homo sapiens Primates ATR ATR ncbigene_synonym ANTXR1 84168
Homo sapiens Primates ATR ATR ncbigene_synonym MMAB 326625
Homo sapiens Primates ATR ATR ncbigene_synonym SERPINA2 390502
Homo sapiens Primates ATM ATM ncbigene_symbol ATM 472
Homo sapiens Primates Chk2 CHK2 ncbigene_synonym CHEK2 11200
Homo sapiens Primates p53 P53 ncbigene_synonym TP53 7157
Homo sapiens Primates p53 P53 famplex_relations TP63 8626
Homo sapiens Primates p53 P53 famplex_relations TP73 7161
Homo sapiens Primates PUMA PUMA ncbigene_synonym BBC3 27113
Homo sapiens Primates ase ASE ncbigene_synonym ARSL 415
Homo sapiens Primates BAX BAX ncbigene_symbol BAX 581
Homo sapiens Primates APAF1 APAF1 ncbigene_symbol APAF1 317
Drosophila melanogaster Invertebrates DRS DRS ncbigene_symbol Drs 38419
Drosophila melanogaster Invertebrates DRS DRS ncbigene_synonym AspRS 36420
Drosophila melanogaster Invertebrates DRS DRS ncbigene_synonym Dro 36635
Drosophila melanogaster Invertebrates Fas FAS ncbigene_synonym Fas2 31364
Drosophila melanogaster Invertebrates Fas FAS ncbigene_synonym FASN1 33524
Drosophila melanogaster Invertebrates Fas FAS ncbigene_synonym Fas3 35097
Drosophila melanogaster Invertebrates Fas FAS ncbigene_synonym fand 36514
Drosophila melanogaster Invertebrates Fas FAS ncbigene_synonym tei 36521
Drosophila melanogaster Invertebrates Fas FAS ncbigene_synonym rg 44531
Drosophila melanogaster Invertebrates Fas FAS ncbigene_synonym FASN2 117361
Drosophila melanogaster Invertebrates Fas FAS ncbigene_synonym FASN3 3355111
Drosophila melanogaster Invertebrates Akt AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates NOM NOM ncbigene_symbol nom 41038
Drosophila melanogaster Invertebrates ATR ATR ncbigene_synonym mei-41 32608
Drosophila melanogaster Invertebrates ATR ATR ncbigene_synonym put 41772
Drosophila melanogaster Invertebrates ATR ATR ncbigene_synonym RYa-R 43253
Drosophila melanogaster Invertebrates ATM ATM ncbigene_synonym tefu 41839
Drosophila melanogaster Invertebrates Chk2 CHK2 ncbigene_synonym lok 35288
Drosophila melanogaster Invertebrates p53 P53 ncbigene_symbol p53 2768677
Drosophila melanogaster Invertebrates p53 P53 ncbigene_synonym betaTub60D 37888
Drosophila melanogaster Invertebrates p53 P53 ncbigene_synonym hth 41273
Drosophila melanogaster Invertebrates ase ASE ncbigene_symbol ase 30985
Drosophila melanogaster Invertebrates APAF1 APAF1 ncbigene_synonym Dark 36914
Danio rerio Vertebrates PERP PERP ncbigene_symbol perp 494479
Danio rerio Vertebrates Fas FAS ncbigene_symbol fas 768248
Danio rerio Vertebrates ATR ATR ncbigene_symbol atr 567770
Danio rerio Vertebrates ATM ATM ncbigene_symbol atm 403064
Danio rerio Vertebrates p53 P53 ncbigene_synonym tp53 30590
Danio rerio Vertebrates BAX BAX ncbigene_synonym baxa 58081
Danio rerio Vertebrates APAF1 APAF1 ncbigene_symbol apaf1 58131

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID