BTK signaling pathway

BTK signaling pathway. BTK translocates to the plasma membrane by interacting with PIP3 to become membrane-bound where it undergoes sequential activation through trans-phosphorylation by Lyn and Syk kinases, followed by autophosphorylation. The downstream substrates of activated BTK and their associated signaling cascades are indicated.
BTK signaling pathway
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Publication

Ibrutinib and novel BTK inhibitors in clinical development. (2013) Akintunde Akinleye, et al. J Hematol Oncol. 2013;6:59-59. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates PI3-K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3-K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3-K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3-K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3-K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3-K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3-K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3-K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3-K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3-K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates Syk SYK ncbigene_symbol SYK 6850
Homo sapiens Primates Lyn LYN ncbigene_symbol LYN 4067
Homo sapiens Primates BLNK BLNK ncbigene_symbol BLNK 29760
Homo sapiens Primates IKK IKK famplex_relations CHUK 1147
Homo sapiens Primates IKK IKK famplex_relations IKBKB 3551
Homo sapiens Primates IKK IKK famplex_relations IKBKG 8517
Homo sapiens Primates IKK IKK famplex_relations IKBKE 9641
Homo sapiens Primates IKK IKK famplex_relations TBK1 29110
Homo sapiens Primates STAT3 STAT3 ncbigene_symbol STAT3 6774
Homo sapiens Primates BAP-135 BAP135 ncbigene_synonym GTF2I 2969
Homo sapiens Primates NF-KB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates PKC PKC ncbigene_synonym PRRT2 112476
Homo sapiens Primates PKC PKC famplex_relations PRKCA 5578
Homo sapiens Primates PKC PKC famplex_relations PRKCB 5579
Homo sapiens Primates PKC PKC famplex_relations PRKCD 5580
Homo sapiens Primates PKC PKC famplex_relations PRKCE 5581
Homo sapiens Primates PKC PKC famplex_relations PRKCG 5582
Homo sapiens Primates PKC PKC famplex_relations PRKCH 5583
Homo sapiens Primates PKC PKC famplex_relations PRKCI 5584
Homo sapiens Primates PKC PKC famplex_relations PRKCQ 5588
Homo sapiens Primates PKC PKC famplex_relations PRKCZ 5590
Homo sapiens Primates PKC PKC famplex_relations PRKD3 23683
Homo sapiens Primates MEK/ERK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates MEK/ERK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates MEK/ERK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates MEK/ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates MEK/ERK ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates MEK/ERK ERK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates p38 P38 ncbigene_synonym CRK 1398
Homo sapiens Primates p38 P38 ncbigene_synonym AIMP2 7965
Homo sapiens Primates p38 P38 ncbigene_synonym GRAP2 9402
Homo sapiens Primates p38 P38 ncbigene_synonym AHSA1 10598
Homo sapiens Primates p38 P38 ncbigene_synonym POLDIP2 26073
Danio rerio Vertebrates Receptor RECEPTOR ncbigene_synonym kita 30256
Danio rerio Vertebrates Receptor RECEPTOR ncbigene_synonym ngfra 100535003
Danio rerio Vertebrates Syk SYK ncbigene_symbol syk 405769
Danio rerio Vertebrates Lyn LYN ncbigene_symbol lyn 447804
Danio rerio Vertebrates Lyn LYN ncbigene_synonym si:ch73-206d17.1 561155
Danio rerio Vertebrates BLNK BLNK ncbigene_symbol blnk 405764
Danio rerio Vertebrates STAT3 STAT3 ncbigene_symbol stat3 30767
Danio rerio Vertebrates p38 P38 ncbigene_synonym mapk14a 65237
Danio rerio Vertebrates JNK JNK ncbigene_synonym mapk8b 65236

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID