An illustration of two pathways for GABA synthesis from glutamine

An illustration of two pathways for GABA synthesis from glutamine. The bold arrow illustrates the predominant pathway where the carbon skeleton of glutamine is metabolized via the TCA cycle prior to synthesis of GABA. The thin arrow illustrates the direct synthesis of GABA from glutamine without involvement of the TCA cycle. Note that AAT is present in both the cytosol and the mitochondrial matrix. αKG, α-ketoglutarate; PAG, phosphate-activated glutaminase; ATT, aspartate aminotransferase; GAD, glutamate decarboxylase.

Publication

Astrocytic Control of Biosynthesis and Turnover of the Neurotransmitters Glutamate and GABA. (2013) Arne Schousboe, et al. Front Endocrinol (Lausanne). 2013;4:102. Figure: F3. All organisms Mus musculus Drosophila melanogaster

Disease mentions