Example metabolic network involving glycolysis and pentose phosphate pathway

Example metabolic network involving glycolysis and pentose phosphate pathway []. Reaction arcs with a white circle indicate the reaction is reversible. Abbreviations of enzymes: Eno, enolase; Fba, fructose 1,6-bisphosphate aldolase; Fbp, fructose 1,6-bisphosphatase; Gap, glyceraldehydes 3-phosphate dehydrogenase; Gnd, phosphogluconate dehydrogenase (decarboxylating); Gpm, phosphoglycerate mutase; Hex1, hexokinase; Pfk, 6-phosphofructokinase; Pgi, phosphoglucoisomerase; Pgk, phosphoglycerate kinase; Pgl, phosphogluconolactonase; Pyk, pyruvate kinase; Rpe, ribulose-phosphate 3-epimerase; Rpi, ribose 5-phosphate isomerase; Tal, transaldolase; TktI, transketolase; TktII, transketolase; TpiA, triosephosphate isomerase; Zwf, glucose 6-phosphate dehydrogenase. Abbreviation of metabolites: 1,3BPG, 3-Phospho-D-glyceroyl phosphate; 2PG, D-Glycerate 2-phosphate; 3PG, 3-Phospho-D-glycerate; 6PG, 6-Phospho-D-gluconate; D-Glc, D-Glucose; DHAP, Dihydroxyacetone phosphate; Ery4P, D-Erythrose 4-phosphate; F6P, D-Fructose 6-phosphate; FP2, D-Fructose 1,6-bisphosphate; G6P, D-Glucose 6-phosphate; GAP, Glyceraldehyde 3-phosphate; GO6P, 6-phospho-D-glucono-1,5-lactone; PEP, phosphoenolpyruvate; Pyr, pyruvate; R5P, alpha-D-Ribose 5-phosphate; Ru5P, D-Ribulose 5-phosphate; Sed7P, sedoheptulose 7-phosphate; Xyl5P, D-Xylulose 5-phosphate.

Publication

A network-based approach for predicting key enzymes explaining metabolite abundance alterations in a disease phenotype. (2013) Jon Pey, et al. BMC Syst Biol. 2013;7:62-62. Figure: F2. All organisms Homo sapiens Drosophila melanogaster

Disease mentions