Hypothetical gastrin-CCKBR signal transduction pathway

Hypothetical gastrin-CCKBR signal transduction pathway. Gastrin signaling through CCKBR causes PI3 kinase activation and the production of phosphatidylinositol 4,5-trisphosphate (PIP3), which in turn increases the binding of PLC to the plasma membrane. PLC then activates PKCα through both diacylglycerol (DAG) and calcium, and PKCα, but not AKT, causes the phosphorylation of NHE3 and S6.
Hypothetical gastrin-CCKBR signal transduction pathway
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Publication

Gastrin Induces Sodium-Hydrogen Exchanger 3 Phosphorylation and mTOR Activation via a Phosphoinositide 3-Kinase-/Protein Kinase C-Dependent but AKT-Independent Pathway in Renal Proximal Tubule Cells Derived From a Normotensive Male Human. (2013) Tianbing Liu, et al. Endocrinology. 2013 Feb;154(2):865-875. Figure: F7.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates NHE3 NHE3 ncbigene_synonym SLC9A3 6550
Homo sapiens Primates P-S6↑ PS6 ncbigene_synonym TAS2R63P 338413
Homo sapiens Primates CCK2R CCK2R ncbigene_synonym CCKBR 887
Homo sapiens Primates S6K S6K ncbigene_synonym RPS6KB1 6198
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates mTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates PLC PLC ncbigene_synonym HSPG2 3339
Homo sapiens Primates PLC PLC famplex_relations PLCE1 51196
Homo sapiens Primates PLC PLC famplex_relations PLCZ1 89869
Homo sapiens Primates PLC PLC famplex_relations PLCB1 23236
Homo sapiens Primates PLC PLC famplex_relations PLCB2 5330
Homo sapiens Primates PLC PLC famplex_relations PLCB3 5331
Homo sapiens Primates PLC PLC famplex_relations PLCB4 5332
Homo sapiens Primates PLC PLC famplex_relations PLCD1 5333
Homo sapiens Primates PLC PLC famplex_relations PLCD3 113026
Homo sapiens Primates PLC PLC famplex_relations PLCD4 84812
Homo sapiens Primates PLC PLC famplex_relations PLCG1 5335
Homo sapiens Primates PLC PLC famplex_relations PLCG2 5336
Homo sapiens Primates PKCA PKCA ncbigene_synonym PRKCA 5578
Drosophila melanogaster Invertebrates NHE3 NHE3 ncbigene_symbol Nhe3 33939
Drosophila melanogaster Invertebrates S6K S6K ncbigene_symbol S6k 38654
Drosophila melanogaster Invertebrates AKT AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates mTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates mTOR MTOR ncbigene_synonym Tor 47396
Drosophila melanogaster Invertebrates PLC PLC ncbigene_synonym norpA 31376
Drosophila melanogaster Invertebrates PLC PLC ncbigene_synonym sl 32601
Drosophila melanogaster Invertebrates PLC PLC ncbigene_synonym Plc21C 33204

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID