Schematic representation of the ergosterol biosynthetic pathway in C
Schematic representation of the ergosterol biosynthetic pathway in C. glabrata showing the structure of sterols used in the present study. (A) Classical pathway; (B) sterol intermediates that accumulate following azole inhibition of sterol 14α-demethylase (ERG11 protein); (C) end product ergosterol, the binding target of polyene antifungals; (D) cholesterol and related sterol intermediates.
Publication
Facultative Sterol Uptake in an Ergosterol-Deficient Clinical Isolate of Candida glabrata Harboring a Missense Mutation in ERG11 and Exhibiting Cross-Resistance to Azoles and Amphotericin B. (2012) Claire M. Hull, et al. Antimicrob Agents Chemother. 2012 Aug;56(8):4223-4232. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Saccharomyces cerevisiae S288C | Plants and Fungi | ERG25, | ERG25 | ncbigene_symbol | ERG25 | 852951 |
| Saccharomyces cerevisiae S288C | Plants and Fungi | ERG26, | ERG26 | ncbigene_symbol | ERG26 | 852883 |
| Saccharomyces cerevisiae S288C | Plants and Fungi | ERG27 | ERG27 | ncbigene_symbol | ERG27 | 850790 |
| Saccharomyces cerevisiae S288C | Plants and Fungi | ERG6 | ERG6 | ncbigene_symbol | ERG6 | 855003 |
| Saccharomyces cerevisiae S288C | Plants and Fungi | ERG11 | ERG11 | ncbigene_symbol | ERG11 | 856398 |
| Saccharomyces cerevisiae S288C | Plants and Fungi | ERG24 | ERG24 | ncbigene_symbol | ERG24 | 855441 |
| Saccharomyces cerevisiae S288C | Plants and Fungi | ERG3 | ERG3 | ncbigene_symbol | ERG3 | 850745 |
| Saccharomyces cerevisiae S288C | Plants and Fungi | ERG2 | ERG2 | ncbigene_symbol | ERG2 | 855242 |
| Saccharomyces cerevisiae S288C | Plants and Fungi | ERG4 | ERG4 | ncbigene_symbol | ERG4 | 852872 |
| Saccharomyces cerevisiae S288C | Plants and Fungi | ERG5 | ERG5 | ncbigene_symbol | ERG5 | 855029 |
| Homo sapiens | Primates | ERG25, | ERG25 | ncbigene_synonym | MSMO1 | 6307 |
| Homo sapiens | Primates | ERG3 | ERG3 | ncbigene_synonym | ERG | 2078 |
| Homo sapiens | Primates | ERG3 | ERG3 | ncbigene_synonym | SC5D | 6309 |
| Homo sapiens | Primates | ERG3 | ERG3 | ncbigene_synonym | KCNH7 | 90134 |
| Homo sapiens | Primates | ERG2 | ERG2 | ncbigene_synonym | KCNH6 | 81033 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Eburicol | eburicol | mesh:C014520 | ebericol | chebi:70315 |
| 4,14a-Dimethyl zymosterol | NA | mesh:C015582 | ||
| 4,4-Dimethyl zymosterol | NA | mesh:C015582 | ||
| 4-Methyl zymosterol | NA | mesh:C015582 | ||
| Zymosterol | NA | mesh:C015582 | ||
| Fecosterol | fecosterol | mesh:C039241 | fecosterol | chebi:17038 |
| Methyl fecosterol | fecosterol | mesh:C039241 | fecosterol | chebi:17038 |
| Episterol | episterol | mesh:C060242 | episterol | chebi:23929 |
| Azole | NA | mesh:D001393 | ||
| Cholestanol | Cholestanols | mesh:D002777 | bile alcohol | chebi:50420 |
| Cholesterol | Cholesterol | mesh:D002784 | cholesterol | chebi:16113 |
| Ergosterol | Ergosterol | mesh:D004875 | ergosterol | chebi:16933 |
| Lanosterol | Lanosterol | mesh:D007810 | lanosterol | chebi:16521 |
| Polyene | Polyenes | mesh:D011090 | polyene | chebi:48121 |
| Sterol | Sterols | mesh:D013261 | sterol | chebi:15889 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|