AmyloidB precursor protein (APP) processing pathway leading to AD

Schematic of amyloid-β precursor protein (APP) processing pathway leading to AD. Amyloidogenic processing of APP generates Aβ, a hydrophobic, neurotoxic, self-aggregating 40–42 amino acid peptide that accumulates preferentially within amyloid plaques. Recent research suggests that APP processing can result in a number of toxic fragments, including N- and C-terminal peptides that may induce neuronal dysfunction, degeneration and death leading to the hypothesis that a number of APP fragments are toxic to nerve cells.

Publication

Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-β peptide and τ levels: target engagement, tolerability and pharmacokinetics in humans. (2012) Maria L Maccecchini, et al. J Neurol Neurosurg Psychiatry. 2012 Sep;83(9):894-902. Figure: F1. Drosophila melanogaster

Disease mentions