Intracellular signaling pathway of endocannabinoid system in neuroprotection

Intracellular signaling pathway of endocannabinoid system in neuroprotection. This graph shows the endocannabinoid system and the post-receptor signaling pathway involved in its neuroprotective effect. (a) signaling pathway of CB1R in neuroprotection; (b) signaling pathway of CB2R in neuroprotection. AEA: N-arach-idonoyl-ethanolamine-anandamide; 2-AG: 2-arachidonylglycerol; CB1R: cannabinoid receptor type 1; PLC: phospholipase c; IP3: inositol triphosphate; ER: endoplasmic reticulum; DAG: diacylglycerol; FAN: factor associated with neutral sphingomyelinase; AC: adenylatecyclase; cAMP: cyclic adenosine monophosphate; PI3K: phosphatidylinositol 3-kinase; MAPK: mitogen-activated protein kinase; εPKC: epsilon protein kinase C; PKA: protein kinase A; AKT: protein kinase B.
Intracellular signaling pathway of endocannabinoid system in neuroprotection
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Publication

Electroacupuncture Pretreatment as a Novel Avenue to Protect Brain against Ischemia and Reperfusion Injury. (2012) Xin Li, et al. Evid Based Complement Alternat Med. 2012;2012:195397. Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents CBR CBR ncbigene_synonym Cbr1 12408
Mus musculus Rodents CBR CBR ncbigene_synonym Cnr1 12801
Mus musculus Rodents PLC PLC ncbigene_synonym Hspg2 15530
Mus musculus Rodents Gs GS ncbigene_symbol gs 14835
Mus musculus Rodents Gs GS ncbigene_symbol Gs 109550
Mus musculus Rodents AC AC ncbigene_symbol ac 11358
Mus musculus Rodents FAN FAN ncbigene_synonym Nsmaf 18201
Mus musculus Rodents PI3K PI3K ncbigene_synonym Pik3r1 18708
Mus musculus Rodents CB2R CB2R ncbigene_synonym Cnr2 12802
Mus musculus Rodents Akt AKT ncbigene_synonym Akt1 11651
Homo sapiens Primates CBR CBR ncbigene_synonym CBR1 873
Homo sapiens Primates CBR CBR ncbigene_synonym CNR1 1268
Homo sapiens Primates PLC PLC ncbigene_synonym HSPG2 3339
Homo sapiens Primates PLC PLC famplex_relations PLCE1 51196
Homo sapiens Primates PLC PLC famplex_relations PLCZ1 89869
Homo sapiens Primates PLC PLC famplex_relations PLCB1 23236
Homo sapiens Primates PLC PLC famplex_relations PLCB2 5330
Homo sapiens Primates PLC PLC famplex_relations PLCB3 5331
Homo sapiens Primates PLC PLC famplex_relations PLCB4 5332
Homo sapiens Primates PLC PLC famplex_relations PLCD1 5333
Homo sapiens Primates PLC PLC famplex_relations PLCD3 113026
Homo sapiens Primates PLC PLC famplex_relations PLCD4 84812
Homo sapiens Primates PLC PLC famplex_relations PLCG1 5335
Homo sapiens Primates PLC PLC famplex_relations PLCG2 5336
Homo sapiens Primates Gq GQ famplex_relations GNAQ 2776
Homo sapiens Primates Gq GQ famplex_relations GNA11 2767
Homo sapiens Primates Gq GQ famplex_relations GNA14 9630
Homo sapiens Primates Gq GQ famplex_relations GNA15 2769
Homo sapiens Primates Gs GS famplex_relations GNAS 2778
Homo sapiens Primates Gs GS famplex_relations GNAL 2774
Homo sapiens Primates Gi/oGsGq GI famplex_relations GNAO1 2775
Homo sapiens Primates Gi/oGsGq GI famplex_relations GNAI1 2770
Homo sapiens Primates Gi/oGsGq GI famplex_relations GNAI2 2771
Homo sapiens Primates Gi/oGsGq GI famplex_relations GNAI3 2773
Homo sapiens Primates Gi/oGsGq GI famplex_relations GNAT1 2779
Homo sapiens Primates Gi/oGsGq GI famplex_relations GNAT2 2780
Homo sapiens Primates Gi/oGsGq GI famplex_relations GNAT3 346562
Homo sapiens Primates Gi/oGsGq GI famplex_relations GNAZ 2781
Homo sapiens Primates IP:Ca2+ IPCA2 ncbigene_synonym SLC45A3 85414
Homo sapiens Primates AC ADCY famplex_relations ADCY1 107
Homo sapiens Primates AC ADCY famplex_relations ADCY2 108
Homo sapiens Primates AC ADCY famplex_relations ADCY3 109
Homo sapiens Primates AC ADCY famplex_relations ADCY4 196883
Homo sapiens Primates AC ADCY famplex_relations ADCY5 111
Homo sapiens Primates AC ADCY famplex_relations ADCY6 112
Homo sapiens Primates AC ADCY famplex_relations ADCY7 113
Homo sapiens Primates AC ADCY famplex_relations ADCY8 114
Homo sapiens Primates AC ADCY famplex_relations ADCY9 115
Homo sapiens Primates AC ADCY famplex_relations ADCY10 55811
Homo sapiens Primates FAN FAN ncbigene_synonym NSMAF 8439
Homo sapiens Primates FAN FAN ncbigene_synonym CNTRL 11064
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates MAPK< MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK< MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK< MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK< MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK< MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK< MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK< MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK< MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK< MAPK famplex_relations MAPK10 5602
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates PKA PKA famplex_relations PRKAR1A 5573
Homo sapiens Primates PKA PKA famplex_relations PRKAR1B 5575
Homo sapiens Primates PKA PKA famplex_relations PRKAR2A 5576
Homo sapiens Primates PKA PKA famplex_relations PRKAR2B 5577
Homo sapiens Primates PKA PKA famplex_relations PRKACA 5566
Homo sapiens Primates PKA PKA famplex_relations PRKACB 5567
Homo sapiens Primates PKA PKA famplex_relations PRKACG 5568
Drosophila melanogaster Invertebrates AEA AEA ncbigene_synonym dv 45286
Drosophila melanogaster Invertebrates CB CB ncbigene_symbol cb 247976
Drosophila melanogaster Invertebrates PLC PLC ncbigene_synonym norpA 31376
Drosophila melanogaster Invertebrates PLC PLC ncbigene_synonym sl 32601
Drosophila melanogaster Invertebrates PLC PLC ncbigene_synonym Plc21C 33204
Drosophila melanogaster Invertebrates Gs GS ncbigene_symbol gs 5656925
Drosophila melanogaster Invertebrates Gi/o GO ncbigene_symbol Go 49413
Drosophila melanogaster Invertebrates AC AC ncbigene_symbol ac 30981
Drosophila melanogaster Invertebrates FAN FAN ncbigene_symbol fan 43926
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates MAPK< MAPK ncbigene_synonym MKP-4 32963
Drosophila melanogaster Invertebrates MAPK< MAPK ncbigene_synonym p38b 34780
Drosophila melanogaster Invertebrates MAPK< MAPK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates EPKC EPKC ncbigene_synonym inaC 36897
Drosophila melanogaster Invertebrates Akt AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates PKA PKA ncbigene_synonym Pka-C1 34284
Drosophila melanogaster Invertebrates PKA PKA ncbigene_synonym Pka-R2 36041
Drosophila melanogaster Invertebrates PKA PKA ncbigene_synonym Pka-C3 39733
Drosophila melanogaster Invertebrates PKA PKA ncbigene_synonym Pka-R1 40305
Drosophila melanogaster Invertebrates PKA PKA ncbigene_synonym Pka-C2 43644

Chemical mentions

Word Match MeSH Name ChEBI
Ceramide Ceramides mesh:D002518 ceramide chebi:17761

Disease mentions

Word Match MeSH Name DOID